Veterinary Pharmacology and Therapeutics

The editorsJim E. Riviere, DVM, PhD, DSc (hon), ATS, is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA.

Mark G. Papich, DVM, MS, Diplomate ACVCP, has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA

Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species.
Provides current, detailed information on using drug therapies in all major domestic animal species
Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine
Includes extensive tables of pharmacokinetic data, products available, and dosage regimens
Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology
Includes access to a companion website with the figures from the book in PowerPoint

Contributors xiii

Preface xix

About the Companion Website xxi

Section ?I Principles of Pharmacology 1

Veterinary Pharmacology: An Introduction to the Discipline 3
Jim E. Riviere and Mark G. Papich

Absorption, Distribution, Metabolism, and Elimination 8
Jim E. Riviere

Pharmacokinetics 41
Jim E. Riviere

Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65
Pierre-Louis Toutain

Principles of Pharmaceutics and Veterinary Dosage Forms 87
Raafat M. Fahmy and Marilyn N. Martinez

Section ?f Drugs Acting on the Autonomic Nervous System 111

Introduction to the Autonomic Nervous Systemand Autonomic Pharmacology 113
Joshua A. Rowe, RoseM.McMurphy, Barbara J. Lutjemeier, andMichael J. Kenney

Adrenergic Receptor Agonists and Antagonists 131
Rose M.McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney

Cholinergic Pharmacology: Autonomic Drugs 151
RoseM.McMurphy, Elizabeth G. Davis, Amy J. Rankin,Marjory A. Artzer, Barbara J. Lutjemeier, andMichael J. Kenney

Section ?g Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165

Introduction to Drugs Acting on the Central Nervous Systemand Principles of Anesthesiology 167
Peter J. Pascoe and Eugene P. Steffey

Neuromuscular Blocking Agents 194
Diane E.Mason and Christopher L. Norkus

Inhalation Anesthetics 216
Robert J. Brosnan and Eugene P. Steffey

Injectable Anesthetic Agents 247
Lysa P. Posner

Opioid Analgesic Drugs 281
Butch KuKanich andMark G. Papich

Sedatives and Tranquilizers 324
Lysa P. Posner

Local Anesthetics 369
Thomas W. Vickroy

Euthanizing Agents 387
Anna Hampton

Anticonvulsant Drugs 395
Mark G. Papich

Drugs Affecting Animal Behavior 416
Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich

Section ?h Autacoids and Antiinflammatory Drugs 449

Histamine, Serotonin, and their Antagonists 451
Wolfgang B aumer

Analgesic, Antiinflammatory, Antipyretic Drugs 467
Peter Lees

Section ?i Drugs Acting on the Cardiovascular System 501

Digitalis, Positive Inotropes, and Vasodilators 503
Clarke E. Atkins and Marisa K. Ames

Antiarrhythmic Agents 537
Kathryn M. Meurs and Jim E. Riviere

Section ?j Drugs Affecting Renal Function and Fluid-Electrolyte Balance 553

Principles of Acid-Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555
Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar

Diuretics and Renal Pharmacology 593
Butch Kukanich and Deborah T. Kochevar

Section ?k Drugs Acting on Blood and Blood Elements 623

Anticoagulant, Antiplatelet, and Hemostatic Drugs 625
Mark G. Papich

Section ?l Endocrine Pharmacology 647

Hypothalamic and Pituitary Hormones 649
Srujana Rayalam,Margarethe Hoenig, and Duncan C. Ferguson

Hormones Affecting Reproduction 674
Wolfgang B aumer, C. Scott Bailey, and John Gadsby

Thyroid Hormone and Antithyroid Drugs 691
Duncan C. Ferguson

Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729
Duncan C. Ferguson and Margarethe Hoenig

Drugs Influencing Glucose Metabolism 763
Margarethe Hoenig

Chemotherapy of Microbial Diseases 779

Antiseptics and Disinfectants 781
Megan E. Jacob

Sulfonamides and Potentiated Sulfonamides 796
Mark G. Papich

beta-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 826
Mark G. Papich

Tetracycline Antibiotics 858
Mark G. Papich and Jim E. Riviere

Aminoglycoside Antibiotics 877
Mark G. Papich and Jim E. Riviere

Chloramphenicol and Derivatives, Macrolides, Lincosamides, andMiscellaneous Antimicrobials 903
Mark G. Papich

Fluoroquinolone Antimicrobial Drugs 953
Mark G. Papich

Antifungal and Antiviral Drugs 988
Jennifer L. Davis and LaraMaxwell

Section ?I?e Chemotherapy of Parasitic Diseases 1033

Antinematodal Drugs 1035
Carlos E. Lanusse, JuanM. Sallovitz, Sergio F. S

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