Xenotransplantation: Basic Research And Clinical Applications

Xenotransplantation might well provide a revolutionary way of augmenting the function of diseased tissues or replacing organs. This possibility has been advanced by newly acquired understanding of the biological and immunological obstacles to conducting transplantation between species. In Xenotransplantation: Basic Research and Clinical Applications, internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft, and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.
Comprehensive and authoritative, Xenotransplantation: Basic Research and Clinical Applications provides basic and clinical investigators, as well as transplant surgeons, with today's most thorough and up-to-date compendium of vital information on all the scientific and technological aspects of xenotransplantation. Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.

Molecular and Cellular Hurdles to Xenotransplantation
Jeffrey L. Platt
Pathological Responses to Xenotransplantation
Matilde Bustos and Jeffrey L. Platt
Natural Xenoreactive Antibodies
Uri Galili
Specificity of Xenoreactive Natural Antibodies
William Parker, Paul B. Yu, and Yuko C. Nakamura
Biophysical Properties of Xenoreactive Natural Antibodies
William Parker, Ryan C. Fields, and Yuko C. Nakamura
The Origin of Xenoreactive Natural Antibodies
Paul B. Yu
Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies
Mauro S. Sandrin and Ian F. C. McKenzie
The Complement Barrier to Xenotransplantation
Agustin P. Dalmasso
Defects and Amplification of Costimulation Across the Species
Nicola Rogers and Robert Lechler
Antibody-Dependent Effects on Cellular Immunity
Antonello Pileggi, R. Damaris Molano, Thierry Berney, and Luca Inverardi
Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation
Simon C. Robson
Current Applications of Cellular Xenografts
Albert S. B. EdgeIndex