Cytokines And Autoimmune Diseases

Although the role of cytokines and chemokines in the induction and regulation of autoimmunity has a vast current literature, there is as yet no clear consensus about the details of this complex process. In Cytokines and Autoimmune Diseases, leading researchers synthesize the available information to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews of the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune disease, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis.
Authoritative and state-of-the-art, Cytokines and Autoimmune Diseases comprehensively integrates the diffuse literature of this dramatically advancing field, and highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease. Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

Part I. Cytokines: Induction and Regulation
Transcriptional Regulation of Cytokine Gene Expression in The Subsets
Jyothi Rengarajan and Laurie H. Glimcher
Chromatin Remodeling and Transcriptional Regulation of Cytokine Gene Expression in T Cells
M. Frances Shannon and Adele F. Holloway
Variant Ligands, Altered T Cell Receptor Signaling, Hierarchial Response Thresholds, and CD4+ Effector Responses
Yasushi Itoh and Ronald N. Germain
The Role of Costimulation in T Cell Differentiation
Janet E. Buhlmann and Arlene H. Sharpe
CD1d-Restricted NK T Cells and Autoimmunity
Mark Exley and S. Brian Wilson
Role of T Cell Death and Cytokines in Autoimmunity
Luk Van Parijs and Abul K. Abbas
Role of Chemokines and Their Receptors in the Induction and Regulation of Autoimmune Disease
Richard M. Ransohoff and William J. Karpus
Part II. Cytokines: Role in Specific Autoimmune Diseases
Cytokines and Resistance to Organ Specific Autoimmune Disease
Benjamin M. Segal and Ethan M. Shevach
The Role of Cytokines in Induction and Regulation of Autoimmune Uveitis
Rachel R. Caspi
Pathogenic and Regulatory Cytokines in Experimental Autoimmune Encephalomyelitis
Estelle Bettelli and Lindsay B. Nicholson
Role of Cytokines in Multiple Sclerosis and Mucosal Tolerance
Howard L. Weiner
Cytokines and Human Type 1 Diabetes
Sally C. Kent, Vissia Viglietta, and David A. Hafler
Cytokines in Human Rheumatoid Arthritis and Murine Models Marie Wahren-Herlenius, Helena Erlandsson Harris, Per Larsson, and Lars Klareskog
Systemic Lupus Erythematosus
Amy E. Wandstrat and Edward K. Wakeland
Myasthenia Gravis
Premkumar Christadoss and Elzbieta Goluszko
Part III. Cytokines and Autoimmunity: A Synthesis
Cytokines in Autoimmune Disease
Vijay K. Kuchroo and Lindsay B. Nicholson