First Do No Harm

First Do No Harm
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A Chemist's Guide to Molecular Design for Reduced Hazard
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Artikel-Nr:
9789814968591
Veröffentl:
2023
Erscheinungsdatum:
12.05.2023
Seiten:
236
Autor:
Paul T. Anastas
Gewicht:
558 g
Format:
236x157x21 mm
Sprache:
Deutsch
Beschreibung:

Predrag V. Petrovic is an associate research scientist at the Yale School of the Environment, Yale University, Connecticut, USA. He obtained a joint PhD in organometallic chemistry at the University of Belgrade, Serbia, and the University of Strasbourg, France, in 2014 where he applied experimental and theoretical approaches in studying non-covalent interactions in organometallic complexes. In 2017, he joined the Center for Green Chemistry and Green Engineering at Yale where his main research focus is setting a foundation for the methodology that will help safer chemical design that complies with the 12 principles of green chemistry by using various computational tools.
This book is the first to provide chemists with useful, practical guidance on how to minimize or avoid a wide range of hazards. Building on the insights gained from the pharmaceutical industry over the past 25 years on how to create desirable biological effects, the authors demonstrate how to avoid undesirable biological effects by design.
1. Hazard 2. ADME 3. Degradability 4. Dose/Response/Risk 5. Pharmacodynamics 6. Classes of Chemicals 7. Design Rules for Safer Chemicals 8. Case studies 9. The Path Forward

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