In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials
Beschreibung:
Toru Takebayashi
Keio University
Graduate School of Health Management
Fujisawa, Kanagawa, Japan
Robert Landsiedel
BASF SE
Experimental Toxicology and Ecology
Ludwigshafen am Rhein, Germany
Masashi Gamo
National Institute of Advanced Industrial Science and Technology (AIST)
Tsukuba, Ibaraki, Japan
This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials.
With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers.