Metastable Systems under Pressure

recently discovered advantages of amorphous forms of medicines/pharmaceutical products which focused a significant part of industry-related efforts on the GFA (Glass Forming Ability) and the glass temperature (T) versus pressure g dependences. 1 b ? 0 ? ? o ? P ? Pg P ? Pg 0 ? ? ? ? T (P ) = F (P )D (P ) =T 1 + exp ? g g ? 0 ? ? ? ? c + Pg ? ? ? ? 400 1 b 0 o ? ? ? ? P ? P P ? P g g 0 ? ? ? ? T (P ) = F (P )D (P ) =T 1 + exp ? g g 0 ? ? ? ? c ? + P max g ? ? ? ? T ~7 GPa g max P ~ 304 K Liquid g 300 1 HS glass 0 200 -1 mSG ?=0. 044 Liquid -2 100 -3 glass ?=0. 12 -1. 2 -0. 9 -0. 6 -0. 3 0. 0 log T 10 scaled -1 0 1 2 3 4 5 6 7 8 9 10 11 12 P (GPa) g 19 Figure 1. T he pressure evolution of the glass temperature in gl Th ye s cerol ol. id curve shows the parameterization of experimental data via the novel, modifie d Glat Sizm elon type equation, given in the Figure.

Proceedings of the NATO Advanced Research Workshop on Metastable Systems under Pressure: Platform for New Technologies and Environmental ApplicationsOdessa, Ukraine4-8 October 2008

recently discovered advantages of amorphous forms of medicines/pharmaceutical products which focused a significant part of industry-related efforts on the GFA (Glass Forming Ability) and the glass temperature (T) versus pressure g dependences. 1 b ? 0 ? ? o ? P ? Pg P ? Pg 0 ? ? ? ? T (P ) = F (P )D (P ) =T 1 + exp ? g g ? 0 ? ? ? ? c + Pg ? ? ? ? 400 1 b 0 o ? ? ? ? P ? P P ? P g g 0 ? ? ? ? T (P ) = F (P )D (P ) =T 1 + exp ? g g 0 ? ? ? ? c ? + P max g ? ? ? ? T ~7 GPa g max P ~ 304 K Liquid g 300 1 HS glass 0 200 -1 mSG ?=0. 044 Liquid -2 100 -3 glass ?=0. 12 -1. 2 -0. 9 -0. 6 -0. 3 0. 0 log T 10 scaled -1 0 1 2 3 4 5 6 7 8 9 10 11 12 P (GPa) g 19 Figure 1. T he pressure evolution of the glass temperature in gl Th ye s cerol ol. id curve shows the parameterization of experimental data via the novel, modifie d Glat Sizm elon type equation, given in the Figure.

Preface: Metastable Systems Under Pressure - The Platform For Novel Fundamental, Technological And Environmental Applications In The 2l Century; S. J. Rzoska et al.- I: Supercooled, Glassy System. The Nature Of Glass: Somethings Are Clear; K. L. Ngai et al.- The Link Between The Pressure Evolution Of the Glass Temperature In Colloidal And Molecular Glass Formers; S. J. Rzoska et al.- Evidences of A Common Scaling Under Cooling And Compression For Slow And Fast Relaxations: Relevance Of Local Modes For The Glass Transition; S. Capaccioli et al.Reorientational relaxation time at the onset of intermolecular cooperativity; C. M Roland, R. Casalini.- Neutron Diffraction As A Tool To Explore The Free Energy Landscape In Orientationally Disordered Phases; M. Rovira-Esteva et al.- A Procedure To Quantify The Short Range OrderOf Disordered Phase; L. C. Pardo et al.- Consistency of the Vogel- Fulcher-Tammann (VFT) Equations For The Temperature-, PressureVolume- And Density- Related Evolutions Of Dynamic Properties In Supercooled and Superpressed Glass Forming Liquids; A. Drozd-Rzoska and S. J. Rzoska.- II: Liquid Crystals. Stability And Metastability In Nematic Glasses: A Computational Study; M. Ambrozic et al.- Phase Ordering In Mixtures Of Liquid Crystals And Nanoparticles; B. Rožic et al.- Glassy Dynamics And Anomalous Decoupling Of The Dc Conductivity And TheStructural Relaxation Time In The Isotropic Phase Of A Rod-Like Liquid Crystalline Compound; A. Drozd-Rzoska and S. J. Rzoska.III: Near-critical Mixtures. An Optical Brillouin Study Of A Re-Entrant Binary Liquid; F. J. Bermejo and L. Letamendia.-New Proposals For Supercritical Fluids Applications; S. J. Rzoska, A. Drozd-Rzoska.- 2d And 3d Quantum Rotors In A Crystal Field: Critical Points, Metastability, And Reentrance; Y. A. Freiman, B. Hetényi.- IV: Water and Liquid- Liquid Transitons. Water And Fluid-Fluid Transition; K. Stokely et al.- Critical Lines In Binary Mixtures OfComponents With Multiple Critical Point; S. Artemenko et al.- About The Shape Of The Melting Line As A Possible Precursor Of A Liquid-Liquid Phase Transition; A.R. Imre, S. J. Rzoska.- Disorder Parameter, Asymmetry And Quasibinodal Ofwater At Negative Pressures; V. B. Rogankov.- Experimental Investigations Of Superheated And Supercooled Water; V. G. Baidakov.-Estimation Of The Explosive Boiling Limit Of Metastable Liquids; A.R. Imre, G. T. Kraska.- Lifetime Of Superheated Water In A Micrometric Synthetic Fluid Inclusion;M El Mekki et al.- Explosive Properties Of Superheated Aqueous Solutions In Volcanic And Hydrothermal Systems; R. Thiéry et al.- Vapour Nucleation In Metastable Water and Solutions By Synthetic Fluid Inclusion Method; K. Shmulovic, L. Mercury.- Method Of Controlled Pulse Heating: Applications For Complex Fluids And Polymers; P.V.Skripov.- V: Other Metastable Systems. Collective Self-Diffusion In Simple Liquids Under Pressure; N. P. Malomuzh et al.- Thermal Conductivity Of Metastable States Of Simple Alcohols; A.I. Krivchikov et al.- Transformation of the strongly hydrogen bonded system into van der Waals one reflected in molecular dynamics; K Kaminski et al.- Effects Of Pressure On Stability Of Biomolecules In Solutions Studied By Neutron Scattering; M.-C. Beiissent-Funel et al.- Generalized Gibbs’ Thermodynamics And Nucleation - Growth Phenomena; J. W.P. Schmelzer.- Self-Assembling Of The Metastable Globular Defects In Superheated Fluorite-Like Crystals; L. N Yakub, E. S. Yakub.- Study Of Metastable States Of The Precipitates In Reactor Steels Under Neutron Irradiation; A.Gokhman, F. Bergner.- Dynamics of systems for monitoring of environment; W. Nawrocki.-