Omics for Personalized Medicine

Debmalya Barh is the Founder and President of the Institute of Integrative Omics and Applied Biotechnology (IIOAB), India, and a consultant biotechnologist having international repute. He is an active researcher in multidisciplinary "omics" fields that include biomarkers, target and targeted drug discovery, pharmacogenomics, neutrigenomics, neuroscience, cancer, and cardiovascular, infectious, and metabolic diseases. He works with nearly 300 researchers from 18 to 20 countries and has published more than 100 papers. He is a well known editor for many research reference books in the foremost domains of "Omics" published by top-ranked international publishers. Dipali Dhawan is a promising researcher in the field of Pharmacogenomics, and Induced Pluripotent and Cancer Stem Cells. A postgraduate in Molecular and Genetic Medicine from University of Sheffield, UK and a PhD in Biotechnology from Nirma University, India, Dr. Dhawan is presently associated with the Institute of Life Sciences, Ahmedabad University, India. She has published many research works and has also been awarded CSIR and DST fellowships. Prof. Nirmal Kumar Ganguly is a distinguished Biotechnology Research Professor, Department of Biotechnology (DBT), GoI. He is the President of Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), as well as that of the Asian Institute of Public Health, Bhubaneswar, Odisha. He is the former Director General of ICMR, New Delhi, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, and National Institute of Biologicals (NIB), Noida. He has published 757 research papers. His major areas of research have been Tropical Diseases, Cardiovascular Diseases and Diarrhoeal Diseases. He has received 116 Awards, including 6 International and 110 National Awards. He has been honored with the prestigious Padma Bhushan Award by Her Excellency, the President of India on 26th January 2008 in the field of "Medicine".

"Omics for Personalized Medicine" will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

This book details how the pharmacogenomics and omics technologies are transforming the medicine and the health care sector for the better. It covers all aspects of pharmacogenomics and its disease-specific applications.

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Pharmaco-Geno-Proteo-Metabolomics and Personalized Medicine-An overview.- Personalized genome, current status and the future of harmacogenomic.- Next generation sequencing (NGS): a revolutionary technology in pharmacogenomics and personalized medicine.- Pharmaco-epigenomics.- Personalized nutrition and drug-nutrient interactions.- Designing and Implementing Pharmacogenomics Study.- Omics approaches and applications in Clinical Trials.- Ethical Considerations in Pharmacogenomics.- Computational Pharmacogenomics.- Pharmacogenomics in the era of personal genomics: a quick guide to online resources and tools.- Pharmacogenomics and Personalized Medicine for Cancer.- Pharmacogenomics in acute myeloid leukemia.- Pharmacogenomics of autoimmune diseases.- Pharmacogenomics and personalized medicine in Parkinsonism.- Pharmacogenomics and personalized medicine in Alzheimer's disease.- Pharmacogenomics and Personalized Medicine in Mood Disorders.- Pharmacogenetics of opioid and alcohol addiction.- Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome (RDS): Stratification of Addiction Risk and Mesolimbic Nutrigenomic Manipulation of Hypodopaminergic Function.- Pharmacogenomics of analgesics.- Cardiovascular Disease Pharmacogenomics.- Pharmacogenetics of Oral Anticoagulants.- Pharmacogenomics and personalized medicine of the antiplatelet drugs.- Pharmacogenomics of pulmonary and respiratory diseases.- Pharmacogenomics of Allergy and asthma.- Pharmacogenomics in Type 2 Diabetes mellitus and metabolic disorders.- Pharmacogenomics and Gut microbiota biomarkers in Obesity.- Pharmacogenomics and Personalized Medicine for Infectious Diseases.- Pharmacogenomics of Viral diseases.- Pharmacogenomics of osteoporosis-related bone fractures.- Pharmacogenomics of Gynaecological disorders.- Pharmacogenomics and Personalized medicine in Infertility.- Pharmacogenomics in Ophthalmology.- Personalized medicine in Cell Therapy and Transplantation.- Pharmacogenetics and pharmacogenomics of Chronic Kidney Disease comorbidities and Kidney transplantation.