Potential Resistance By Cancer Cells For Multi-Drugs

Daniel, Esther Priyadharshini
Dr. Esther Priyadharshini has graduate studies with a Ph.D and M.Sc in Bio-Medical Genetics from the VIT University, India in 2016 and 2008, respectively. Her current research interests are in the areas of Cancer Biology, antibiotic resistance, ESBL producing bacteria.

Cancer is a dreadful disease in which the abnormal cells proliferate without control and invade other parts of the body resulting in tumour. Causes for cancer includes tobacco use, excess body weight, inherited genetic mutations, hormones, immune condition, etc. According to the World Health Organization's (WHO) finding, it is expected that annual cancer cases will rise from 14 million in 2012 to 22 within the next two decades. This is a real alarm to the society and gives us a challenging opportunity to break the threat. Despite having treatment for cancer the rate of success is less. The reason is the cancer cells develop resistance for the treatment and regenerate their properties. Therefore this book provides information regarding their resistance for the treatment along with data about few types of cancers and their strategies to overcome treatment. Different types of transporters which are responsible for the resistance of cancer cells during treatment are mentioned. Few are ABC transporters, P-gp, Pten etc. Many drugs with capacity to overcome resistance are listed and included. Cancer cells adapt instantly for every condition and strategies of cancer cells are discussed.