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Metabolic Re-programming of Colorectal Cancer Cells with Resveratrol
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Artikel-Nr:
9786139430383
Veröffentl:
2019
Einband:
Paperback
Erscheinungsdatum:
27.03.2019
Seiten:
172
Autor:
Mariam Hafez
Gewicht:
274 g
Format:
220x150x11 mm
Sprache:
Englisch
Beschreibung:
Hafez, MariamMariam A. Fouad Hafez, PhD Cancer Biology (Pharmacology and Experimental Oncology), Lecturer in Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Egypt.
Resveratrol as a phyto-estrogenic polyphenolic compound extracted from red grapes, has a calorie restriction effect on colorectal cancer cells. It stimulates the metabolic re-programming of cells from the anaerobic glycolysis into oxidative respiration. So that it is called to be a glucose deprivation mimic drug with a chemo- preventive and chemo- therapeutic effects. The calorie restriction effect of resveratrol is the deriving force for the enhanced cytotoxicity and apoptosis and the reduced angiogeneis of colorectal cancer cells.