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Risedronate Effects on Bone Metastasis of Rat Mammary Tumor Cell Lines
Comparison of Effects of Risedronate on Bone Metastasis of Two Malignant Rat Mammary Tumor Cell Lines, MTA & MTB-01
Paperback
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Artikel-Nr:
9783847341529
Veröffentl:
2012
Einband:
Paperback
Erscheinungsdatum:
03.02.2012
Seiten:
128
Autor:
Kelli Boyd
Gewicht:
209 g
Format:
220x150x9 mm
Sprache:
Englisch
Beschreibung:
Dr. Boyd received her undergraduate and DVM degrees from Mississippi State University. She completed a residency and PhD program at the University of Georgia. Her expertise is in comparative pathology with a special interest in pathology of genetically engineered mice and translational research.
When compared to MTA cells, MTB-01 cells were susceptible to risedronateinduced apoptosis, had decreased ability to bind to risedronate-treated bone, and did not produce MMP-2 or MMP-9 proteases. MTA cells were less susceptible to risedronateinduced apoptosis and produced MMP-2. Additionally, adhesion of MTA cells to bone matrix was not diminished by risedronate treatment. Our results suggest that the nonresponsive nature of the MTA cell line may be due to MMP-2 production (possibly allowing ongoing destruction of risedronate-treated bone), continued adhesion to risedronate-treated bone matrix, and decreased susceptibility to risedronate-induced apoptosis.