Piperine Loaded Microspheres in Hepatoprotective Activity

Sahu, Prashant
Dr. Prashant Sahu is a CSIR-Research Associate in DOPS, Dr. H.S. Gour Central University Sagar India. He obtained his PhD degree from the same University and master's degree from SIPS college Sagar. He has 21 research papers, 2 Patents and won several Oral & Poster paper presentation awards including MPCOST 2017 Young Scientist award.

The concept of this book is focused on the miracle potential of Piperine extracted from the natural herb Pippali piper longum. Piperine, a natural alkaloids is used in variety of ailments like worms treatment, asthma, bronchitis, pneumonia, liver diseases etc., avoiding associated side effect. Hepatic diseases befall in numerous categories. They are mainly caused due to viruses, pathogens, drugs toxicity, poisons and alcohol abuse. The Piperine showed significant hepatoprotective activity along with benefits of eliminating the adverse ill-effect of treatment. Targeted drug delivery is a method of delivering medication that increases the concentration of the medication at desired body parts. The study is focused on liver targeting employing Piperine encapsulated biodegradable Chitosan microspheres to achieve prolonged, localize, onsite hepatoprotective potential via oral route. Amalgam of Piperine and biodegradable chitosan microspheres opened novel prospects againsty liver ailments. The current targeting strategy will enhanced the therapeutic efficiency at hepatic region with reduction in undesirable effects to the normal cells and proves as a boon for abolition of liver ailment.