Male Infertility: Molecular Approaches to Diagnosis

Assistance Professor Dr. Ali Hussein Al-Marzoqi (Iraq, Basra city 1980), had PhD in Molecular Genetics from Iraq College of Medicine Babylon University (2012). Member of educational committee at Babylon University College of Science for women, Editorial Board Member in Journal of Cancer Research and Treatment. Had more than 23 published researches

Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In more than half of infertile men, the cause of their infertility is mysterious (idiopathic) and could be congenital or acquired. The causes are known in less than half of these cases, out of which genetic or inherited disease and specific abnormalities in the Y chromosome are major factors. About 10 20 percent of males presenting without sperm in the ejaculate carry a deletion of the Y chromosome Male genetic factor of infertility accounts for about half the cases of couple infertility and in around 50% of cases its etiology remains unknown. Molecular genetic techniques have unveiled a number of etiopathogenetic factors, including microdeletions of the Yq. Y chromosome microdeletions removing the AZoospermia Factor (AZF) regions are the most frequent molecular genetic causes of oligo/azoospermia).