Malignant Lymphomas Other than Hodgkin¿s Disease

A.G. STANSFELD, and J.A.M. VAN UNNIK. In joint discussions in 1974, the Club worked out a new terminology that was acceptable to all members and will hopefully be acceptable to other pathologists. Since then, it has been called the Kiel Classification. We are also pleased that the clinicians belonging to the Kiel Lymphoma Study Group-foremost A. STACHER and G. BRITTINGER have been able to present preliminary data on the clinical relevance of the new classification. Finally, our optimism was fortified by the findings of R.J. LUKES and R.D. COLLINS, which largely concur with ours in both concept and practical significance. This book is divided into six main sections. First, there is a chapter on normal cytology that supplements and, in some respects, revises the presentation given in Part A of this Handbook (1961). H.K. MULLER-HERMELINK played a major role in the writing of the first chapter. The second chapter is a brief description of the light-microscopic techniques that are used in our laboratories and have proved to be suitable for a precise diagnosis of lymph-node diseases.

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One The Cytologic, Histologic, and Functional Bases for a Modern Classification of Lymphomas.- I. Lymphocytes.- II. Immunoblasts (Basophilic Stem Cells).- III. Plasma Cells.- IV. Histomorphology of the B-Cell Region.- V. Histomorphology of the T-Cell Region.- VI. Histochemistry of B- and T-Cell Regions.- VII. Stationary Elements of the Lymph Node.- Two Methodologic Prerequisites for a Differential Diagnosis of Lymphomas.- Appendix: Some Stainings and Cytochemical Reactions Used in Our Laboratories.- Three Classification of Non-Hodgkin's Lymphomas.- I. Historical Review of the Classifications of Lymphomas.- II. Some Ideas for a Modern Lymphoma Classification.- III. A Simplified Cellular Scheme as a Basis for a Modern Classification of Lymphomas.- IV. The Kiel Classification and Its Clinical Relevance.- V. Incidence of the Different Types of Lymphoma in our Material.- Four Histopathology and Diagnosis of Non-Hodgkin's Lymphomas.- I. Malignant Lymphomas of Low-Grade Malignancy.- II. Malignant Lymphomas of High-Grade Malignancy.- Conclusions.- Five Ultrastructure of Non-Hodgkin's Lymphomas.- Remarks on Methods.- I. Low-Grade Malignant Lymphomas.- II. High-Grade Malignant Lymphomas.- Conclusions.- Six The Immunologic and Immunochemical Basis for the Kiel Classification.- I. Immunochemical and Immunologic Methods and Markers and Their Significance for the Characterization of Lymphoid-Cell Populations.- I. Human T-Associated Antigens.- J. Common-ALL Antigen.- K. Human B-Associated Antigens: Ia-Like Antigens.- L. Terminal Deoxynucleotidyl Transferase (Tdt).- M. Receptor for Hemagglutinin A from the Snail Helix Pomatia (HP).- II. Immunologic Findings and Their Relevance to the Classification of Non-Hodgkin's Lymphomas.- I. Malignant Lymphoma, Centrocytic.- Summary andFinal Remarks.- References, Part One.- Parts Two, Three and Four.- Five.- Six.- Author Index.