Pharmacology of GABA and Glycine Neurotransmission

Highlighting the current developments and future directions in GABA and glycine research, this volume covers the major inhibitory neurotransmitters from the molecular mechanisms of signal transduction to their role in health and disease. It is of topical importance because these neurotransmitters are essential for brain function and therapy of diseases such as anxiety disorders, insomnias, epilepsy, depression, spasticity, and memory deficits. Distinguished scientists at the forefront of research contributed reviews on the role of these transmitters in governing neuronal networks, their signalling pathways, their receptors, the pharmacology of GABA A- and GABA B- and GABA C-receptors as well as of GABA- and glycine-transporters, and their role in disease. The volume serves as reference for pharmacologists/toxicologists, neuroscientists, neurologists and psychiatrists.

With contributions by numerous experts

Springer Book Archives

Section I: Physiology of the Neurotransmitters GABA and Glycine.- 1 Physiology of the GABA and Glycine Systems.- Section II: Pharmacology of the GABA System GABAAReceptors.- 2 The Molecular Architecture of GABAA Receptors.- 3 Functions of GABAA-Receptors: Pharmacology and Pathophysiology.- 4 Steroid Modulation of GABAA Receptors.- 5 Allosteric Modulation of GABAA Receptor Function by General Anesthetics and Alcohols.- 6 Anticonv ulsants Acting on the GABA System.- 7 Heterologous Regulation of GABAA Receptors: Protein Phosphorylation.- 8 Tolerance and Dependence to Ligands of the Benzodiazepine Recognition Sites Expressed by GABAA Receptors.- 9 GABAA Receptors and Disease.- 10 GABAC Receptors: Structure, Function and Pharmacology.- GABAB Receptors.- 11 Structure of GABAB Receptors.- 12 Pharmacology of GABAB Receptors.- 13 GABAB Receptor Signaling Pathways.- GABA Transporters.- 14 Structure and Function of GABA Transporters.- 15 Pharmacology of GABA Transporters.- Section III: Pharmacology of the Glycine System.- 16 Structures, Diversity and Pharmacology of Glycine Receptors and Transporters.