Ultrathin Electrochemical Chemo- and Biosensors

Vladimir M. Mirsky is Professor at Regensburg University, Germany. He graduated from Moscow Medical University in 1981 as M.D. in biophysics and went on to study physical chemistry and electrochemistry at the Frumkin Institute of Electrochemistry of the Soviet Academy of Sciences, obtaining his Ph.D. in 1986. He subsequently held an Alexander-von-Humboldt Research Fellowship and a research position at the CNRS Centre of Molecular Biology in France prior to joining the Institute of Analytical Chemistry at Regensburg University in 1995. He editor of two recent books, "Ultrathin Electrochemical Chemo- and Biosensors" and "Combinatorial Methodologies for Development of Chemical and Biological Sensors". His work has led to 18 patents and patent applications as well as some 100 peer-reviewed scientific papers.

Traditional biological sensors, based on enzymatic receptors and potentiometric or amperometric transducers are well reviewed and are nowadays even included extensively in many textbooks. The editors of this volume, the 2nd in the new Springer Series on Chemical and Biosensors, have focussed exclusively on alternative types of chemical and biological sensors or sensor-like structures. Special attention is given to sensor principles based on the use of linear or non-linear impedance spectroscopy.After self-assembled monolayers have become a viable technology for the immobilization of organic molecules on electrodes and for the formation of covalently stabilized receptor layers and even more sophisticated organic nano- and microstructures, this has led to the development of numerous analytical applications of impedometric sensor methods. These new and very promising types of sensors, their technology and performance in real world applications form the main topic of this book written by leading experts from around the world.

I: Receptors.- 1 Antibodies for Biosensors.- 2 Molecularly Imprinted Polymers as Recognition Elements in Sensors.- II: Impedometric and amperometric chemical and biological sensors.- 3 Capacitance Affinity Biosensors.- 4 Immunosensors and DNA Sensors Based on Impedance Spectroscopy.- 5 "Voltohmmetry" - a New Transducer Principle for Electrochemical Sensors..- 6 Electrochemical Sensors for the Detection of Superoxide and Nitric Oxide - Two Biologically Important Radicals.- III: Non-invasive electrical monitoring of living cells.- 7 Living Cells on Chip: Bioanalytical Applications.- 8 Bioanalytical Application of Impedance Analysis: Transducing in Polymer-Based Biosensors and Probes for Living Tissues.- 9 Noninvasive Electrical Sensor Devices to Monitor Living Cells Online.- IV: Lipid membranes as biosensors.- 10 Functional Tethered Bilayer Lipid Membranes.- 11 Electrostatic Potentials of Bilayer Lipid Membranes: Basic Principles and Analytical Applications.- 12 Electrostriction of Supported Lipid Membranes and Their Application in Biosensing.- 13 Transport Proteins on Solid-Supported Membranes: From Basic Research to Drug Discovery.