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Autor: Salvador Moncada
ISBN-13: 9783540360285
Einband: eBook
Seiten: 356
Sprache: Englisch
eBook Typ: PDF
eBook Format: eBook
Kopierschutz: Adobe DRM [Hard-DRM]
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The Vascular Endothelium II

176/II, Handbook of Experimental Pharmacology
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treatmentofvascularpathologies.Interestingly,althoughthis?eldofresearch can now be considered mature, it continues to generate a great deal of new informationatatimewhensomeofitsfruitsare havingadirectimpacton clinical medicine. This is clearly exempli?ed in the contents of most of the chapters. Theconceptofendothelialdysfunction,althoughmootedmanyyearsago, hascometotheforeandhasbeenveryusefulinde?ningasituationwhichmay existlongbeforetheovertsignsofvasculardiseasescanbeidenti?ed.Although VI Preface endothelial dysfunction is likely to comprise a variety of disturbances, it is interesting that these days it is almost exclusively measured as a decrease innitricoxide(NO)-dependentvasculardilatation,eitherinducedbysuitable pharmacologicalagonistsorbyincreasesinblood?ow.Oxidativestress,which isassociatedwiththegenesisofendothelialdysfunction,isaloosetermused tode?neanimbalancebetweenthereleaseofoxygen-derivedfreeradicalsand theanti-oxidantsystemsofthebody.Manyyearsagoourworkestablishedthat reactiveoxygenspeciesareimportantinreducingthelocalconcentrationsof both prostacyclin and NO. It is now clear that free radicals also affect other homeostaticsystemsinthevasculature.However,manythingsremaintobe clari?ed,especiallytheoriginofoxidativestressinearlydisease.
With contributions by numerous experts
This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.
Haemostasis.- Vascular Endothelium and Blood Flow.- Biomechanical Modulation of Endothelial Phenotype: Implications for Health and Disease.- Leucocyte-Endothelial Interactions in Health and Disease.- Endothelial Cell Dysfunction, Injury and Death.- Principles and Therapeutic Implications of Angiogenesis, Vasculogenesis and Arteriogenesis.- Endothelial Cell Senescence.- The Vascular Endothelium in Hypertension.- Vascular Endothelium and Atherosclerosis.- Endothelial Cells and Cancer.- Gene Therapy: Role in Myocardial Protection.

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Autor: Salvador Moncada
ISBN-13 :: 9783540360285
ISBN: 354036028X
Verlag: Springer Berlin
Seiten: 356
Sprache: Englisch
Auflage 2006
Sonstiges: Ebook