Organometallic Chemistry in Industry

Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studiesThis comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions.Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more.Includes rare industrial case studies difficult to find in current literatureHelps readers successfully carry out their own reactionsCovers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylationFeatures a foreword by Nobel Laureate R. H. GrubbsA perfect resource for every R&D researcher in industryUseful for PhD students and postdocs: excellent preparation for a job interviewOrganometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

INDUSTRIAL MILESTONES IN ORGANOMETALLIC CHEMISTRYDESIGN, DEVELOPMENT AND EXECUTION OF A CONTINUOUS FLOW ENABLED API MANUFACTURING ROUTECONTINUOUS MANUFACTURING AS AN ENABLING TECHNOLOGY FOR LOW TEMPERATURE ORGANOMETALLIC CHEMISTRYDEVELOPMENT OF A NICKEL-CATALYZED ENANTIOSELECTIVE MIZOROKI-HECK COUPLINGDEVELOPMENT OF IRON-CATALYZED KUMADA CROSS-COUPLING FOR THE LARGE SCALE PRODUCTION OF ALISKIREN INTERMEDIATEDEVELOPMENT AND SCALE-UP OF A PALLADIUM-CATALYZED INTRAMOLECULAR DIRECT ARYLATION IN THE COMMERCIAL SYNTHESIS OF BECLABUVIRRUTHENIUM CATALYZED C-H ACTIVATED C-C/N/O BOND FORMATION REACTIONS FOR THE PRACTICAL SYNTHESIS OF HETEROCYCLES AND PHARMACEUTICAL AGENTSCROSS-COUPLINGS IN WATER - A BETTER WAY TO ASSEMBLE NEW BONDSASPECTS OF HOMOGENEOUS HYDROGENATION FROM INDUSTRIAL RESEARCHLATEST INDUSTRIAL USES OF OLEFIN METATHESISDEHYDRATIVE DECARBONYLATION