Transporters as Drug Targets

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation.With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

Insights into Transporter Classifications - An Outline of Transporters as Drug TargetsNew Trends in Antidepressant Drug ResearchThe Molecular Basis of the Interaction Between Drugs and Neurotransmitter Transportersgamma-Aminobutyric Acid and Glycine Neurotransmitter TransportersABC-Transporters - From Targets to Antitargets and BackABC Transporters Involved in CholestasisRecent Advances in Structural Modeling of ABC TransportersPET Imaging of ABC Transporters at the Blood-Brain BarrierThe Systems Biology of Transporters - Targeting the Regulatory System for Transporters (FXR, RXR).ANO1 as a Novel Drug TargetLigand Discovery for the Nutrient Transporters ASCT2 and LAT-1 from Homology Modeling and Virtual ScreeningOrganic Anion Transporting Polypeptides as Drug Targets