Posttranscriptional Gene Regulation

Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.

Diese einzige derzeit erhältliche umfassende Monographie zur RNA-Verarbeitung in Eukaryonten-Zellen hebt die Bedeutung der posttranskriptionalen Genregulation für die Pathogenese vieler Krankheiten besonders hervor.

The Role of Co-transcriptional Recruitment of RNA Binding Proteins in the Maintenance of Genomic Stability (Jennifer A. Aoki and James L. Manley)Transcription Termination by RNA Polymerase II (Minkyu Kim and Stephen Buratowski)Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing (Louis Valente Yukio Kawahara, Boris Zinshteyn, Hisashi Iizasa and Kazuko Nishikura)Posttranslational Modification of Sm Proteins: Diverse Roles in sn RNP Assembly and Germ Line Specification (Graydon B. Gonsalvez and A. Gregory Matera)Structure, Function, and Biogenesis of Small Nucleolar Ribonucleoparticles (Katherine S. Godin and Gabriele Varani)Mechanistic Insights into Mammalian pre-mRNA Splicing (Sebastian M. Fica, Eliza C. Small, Melissa Mefford, and Jonathan P. Staley)Splicing Decisions Shape Neuronal Protein Function Across the Transcriptome (Jill A. Dembowski and Paula J. Grabowski)Noncoding RNA: The Major Output of Gene Expression (Matthias Harbers and Piero Carninci)Noncoding RNAs, Neurodevelopment and Neurodegeneration (Mengmeng Chen, Jianwen Deng, Mengxue Yang, Kun Zhu, Jianghong Liu, Li Zhu, and Jane Y. Wu)The Evolution of the Modern RNA World (Ying Chen, Hongzheng Dai and Manyuan Long)