NMR of Biomolecules

NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.

This practical approach title is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.Website: wiley-vch.de/home/nmrbiomol

Website: wiley-vch.de/home/nmrbiomolINTRODUCTIONNMR and its place in Mechanistic Systems Biology (Bertini, McGreevy, Parigi)The structure of biomolecules: fundamentalsStructural features of proteins (Banci, Cantini)Structural features of nucleic acids (Cevec, Jonker, Nozinovic, Richter, Schwalbe)What can be learned about the structure and dynamics of biomolecules from NMRProteins studied by NMR (Ferella, Rosato, Turano)Nucleic acids studied by NMR (Plavec)THE ROLE OF NMR IN THE STUDY OF THE STRUCTURE AND DYNAMICS OF BIOMOLECULESDetermination of protein structure and dynamics (Ferella, Rosato, Turano)DNA (Plavec)RNA (Stefl, Sklenár)Intrinsically disordered proteins (Felli, Pierattelli, Tompa)Paramagnetic molecules (Bertini, Luchinat, Parigi)THE ROLE OF NMR IN THE STUDY OF THE STRUCTURE AND DYNAMICS OF BIOMOLECULAR INTERACTIONSNMR methodologies for the analysis of protein interactions (Madl, Sattler)Metal-mediated interactions (Ciofi-Baffoni)Protein-paramagnetic protein interactions (Keizers, Hiruma, Ubbink)Protein-RNA interactions (Manoharan, Perez-Canadillas, Ramos)Protein-DNA interactions (Kovacic, Boelens)NMR IN DRUG DISCOVERYHigh-throughput screening and fragment-based design: general considerations for lead discovery and optimization (Pellecchia)Ligand-observed NMR in fragment-based approaches (Sledz, Abell, Ciulli)Interactions of metallodrugs with DNA (Sadler)RNA as a drug target (Ferner, Duchardt-Ferner, Rinnenthal, Buck, Wöhnert, Schwalbe)Fluorine NMR spectroscopy for biochemical screening in drug discovery (Dalvit)NMR of peptides (Beck, Frank, Kessler)SOLID-STATE NMRBiomolecular solid state NMR - basics (Barbet-Massin, Pintacuda)Protein dynamics in the solid-state (Lewandowski, Emsley)Microcrystalline proteins - An ideal benchmark for methodology development (Franks, van Rossum, Bardiaux, Ravera, Parigi, Luchinat, Oschkinat)Structural studies of protein fibrils by solid-state NMR (Böckmann, Meier)Membrane proteins (Cukkemane, Renault, Baldus)FRONTIERS IN NMR SPECTROSCOPYDynamic nuclear polarization (Prisner)13C direct detection NMR (Felli, Pierattelli)Speeding up multidimensional NMR data acquisition (Brutscher, Marion, Frydman)Metabolomics (Tenori)In cell NMR spectroscopy (Burz, Cowburn, Dutta, Shekhtman)Structural investigation of cell-free expressed membrane proteins (Sobhanifar, Reckel, Löhr, Bernhard, Dötsch)COMPUTATIONAL ASPECTSGrid computing (Rosato)Protein-protein docking with HADDOCK (Schmitz, Melquiond, de Vries, Karaca, van Dijk, Kastritis, Bonvin)Automated protein structure determination methods (Guerry, Herrmann)NMR structure determination of protein-ligand complexes (Schieborr, Sreeramulu, Schwalbe)SAXS/SANS as methods complementary to NMR (Petoukhov, Svergun)