Heterocycles in Natural Product Synthesis

Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.

Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products.Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail.Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.

PrefacePART I: Strained Heterocycles in the Synthesis of Natural ProductsAZIRIDINES IN NATURAL PRODUCT SYNTHESISIntroductionSynthesis of Natural Products Containing Aziridine UnitsSynthesis of Natural Products Involving the Transformation of an Aziridine MoietyConclusionsAZETIDIINE AND ITS DERIVATIVESIntroductionStructural Description of AzetidinesSynthetic Methodologies for the Formation of Azetidine RingsSynthesis of Mugineic AcidsSynthesis of PenaresidinsStructural Description of Azetidin-2-onesSynthetic Methodologies for the Formation of Azetidin-2-onesSynthesis of PenicillinSynthesis of CephalosporinConclusionEPOXIDES AND OXETANESIntroductionEpoxides in Natural Product SynthesisOxetane in Natural Product SynthesisConclusionPART II: Common Ring Heterocycles in Natural Product SynthesisFURAN AND ITS DERIVATIVESIntroductionNatural Products Containing the Furan RingFuran Derivatives as Reagents in the Synthesis of Natural ProductsSummaryPYRAN AND ITS DERIVATIVESIntroductionApplication of Pyran Moieties in the Synthesis of Natural ProductsConclusionPYRROLE AND ITS DERIVATIVESIntroductionSynthesis of Pyrrole Natural ProductsSynthesis of Non-pyrrole Natural Products from Pyrrole DerivativesConclusionINDOLES AND INDOLIZIDINESIntroductionApplications of Indoles and Indolizidines in the Synthesis of Natural ProductsConclusionPYRIDINE AND ITS DERIVATIVESIntroductionApplication of the Pyridine Moiety in the Synthesis of Natural ProductsConclusionQUINOLINES AND ISOQUINOLINESIntroductionApplication of Quinolines and Isoquinolines in the Synthesis of Natural ProductsConclusionCARBAZOLES AND ACRIDINESIntroduction to CarbazolesTotal Synthesis of Carbazole AlkaloidsIntroduction to AcridinesSynthesis of Acridines and AcridonesTHIOPHENE AND OTHER SULFUR HETEROCYCLESIntroductionSynthesis of Natural Products Containing ThiopheneSynthesis of Natural Products Containing Other Sulfur HeterocyclesConclusionOXAZOLE AND ITS DERIVATIVESIntroductionMono-OxazolesUnconnected Bis- and Tris-OxazolesCyclic Polyheterocyclic Metabolites Containing Single Oxazole ResiduesConjugated Bis-OxazolesTris- and Poly-OxazolesTHIAZOLINE AND THIAZOLE AND THEIR DERIVATIVESIntroductionGeneral Methods for the Synthesis of Thiazoline and Thiazole DerivativesThiazole and Thiazoline-Containing Natural ProductsConclusionsPYRIMIDINE AND IMIDAZOLEGeneral IntroductionPyrimidine-Based Natural ProductsImidazole-Based Natural ProductsConclusionPART III: Natural Products Containing Medium and Large Ring-Sized Heterocyclic SystemsOXEPINES AND AZEPINESIntroductionSynthesis of the Heterocyclic Core of Selected Natural Products Containing OxepinesSynthesis of the Heterocyclic Core of Selected Natural Products Containing AzepinesSynthesis of the Heterocyclic Core of Selected Natural Products Containing OxazapinesConclusionBIOACTIVE MACROCYCLIC NATURAL PRODUCTSGeneralNatural Products Containing AzolesPyridine- and Piperidine-Containing Natural ProductsIndole- and Imidazole-Containing Natural ProductsPyran- and Furan-Containing Natural ProductsPiperazic Acid-Containing Natural ProductsMixed Heterocyclic SystemsConclusions