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Transporters as Drug Carriers
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Artikel-Nr:
9783527627431
Veröffentl:
2009
Einband:
E-Book
Seiten:
449
Autor:
Gerhard F. Ecker
Serie:
44, Methods and Principles in Medicinal Chemistry
eBook Typ:
PDF
eBook Format:
Reflowable E-Book
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:
This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion. As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.
Dieser Band aus der Reihe "Methods and Principles in Medicinal Chemistry" beleuchtet die Rolle molekularer Wirkstofftransporter im Kontext der Therapieoptimierung und der Aufklärung von Wirkstoffresistenzen. Alle bekannten Transporterklassen (vom Mikroorganismus bis zum Menschen) werden vorgestellt.
PART 11 The ABC Transporters: Structural Insights into Drug Transport2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters3 Organic Anion Transporting Polypeptides (Oatps/OATPs)4 CNS Transporters as Drug TargetsPART 25 Bacterial Multidrug Transporters: Molecular and Clinical Aspects6 Pleiotropic drug resistance in yeast and fungal pathogensPART 37 QSAR studies on ABC-transporters: how to deal with polyspecificity8 Drug Transporter PharmacophoresPART 49 Biological Membranes and Drug Transport10 Transport at the Blood-Brain Barrier11 Bile canalicular transporters12 Interplay of Cytochrome P450 Isoenzymes and ABC-transporter13 ABC-Transporter: From target to antitargetPART 314 A Systems Biology View of Drug Transporters15 Drug Transporters in Health and Disease