Nuclear Receptors as Drug Targets

Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.

Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.

Nuclear Receptors as Modern Drug Targets - a Historic PerspectiveTargeting the Nuclear Receptor - Cofactor InteractionUntangling the Estrogen Receptor WebSubtype Selective EstrogensEstrogen Receptors as Therapeutic Targets in Breast CancerProgesterone Receptor and ProgestinesProgesterone Receptor AntagonistsNonsteroidal Tissue Selective Androgen Receptor ModulatorsThe Glucocorticoid Receptor as Target for Classic and Novel Anti-inflammatory Therapy and Novel Glucocorticoid Receptor LigandsVitamin D Analogs as Modulators of Vitamin D Receptor ActionPPARs: Therapeutic Targets for Metabolic Disease and Type 2 DiabetesRetinoids in Clinical UseNuclear Receptors as Targets in Cardiovascular DiseasesNURR77 Family of Nuclear Receptors and its ModulatorsInduction of Drug Metabolism: The Role of Nuclear ReceptorsNuclear Receptor Targeted Screening Libraries and Chemogenomics Approaches