Protein-Lipid Interactions

In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.

In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.

HOW LIPIDS SHAPE PROTEINSLipid Bilayers, Translocons, and the Shaping of Polypeptide StructureFolding and Stability of Monomeric beta-Barrel Membrane ProteinsPrinciples, Kinetics and Stability of Bacteriorhodopsin FoldingPost-Integration Misassembly of Membrane Proteins and DiseaseHOW PROTEINS SHAPE LIPIDSA Census of Ordered Lipids and Detergents in X-ray Crystal Structures of Integral Membrane ProteinsLipid and Detergent Interactions with Membrane Proteins Derived from Solution NMRMEMBRANE PENETRATION BY TOXINSLipid Interactions of alpha-Helical Protein ToxinsMembrane Recognition and Pore Formation by Bacterial Pore-forming ToxinsMechanism of Membrane Permeation and Pore Formation by Antimicrobial PeptidesMECHANISMS OF MEMBRANE FUSIONCell Fusion in Development and DiseaseMolecular Mechanisms of Intracellular Membrane FusionInterplay of Proteins and Lipids in Virus Entry by Membrane FusionCHOLESTEROL, LIPID RAFTS, AND PROTEIN SORTINGProtein-Lipid Interactions in the Formation of Raft MicrodomainsProtein and Lipid Partitioning in Locally Heterogeneous Model MembranesTARGETING OF EXTRINSIC MEMBRANE PROTEIN MODULES TO MEMBRANES AND SIGNAL TRANSDUCTIONIn vitro and Cellular Membrane Binding Mechanisms of Membrane Targeting DomainsStructure and Interactions of C2 Domains at Membrane SurfacesStructural Mechanisms of Allosteric Regulation by Membrane-binding domains