Asymmetric Catalysis on Industrial Scale

Edited by two of the experts in the field, the central aim is to show organic chemists working in process development that enantioselective catalysis is suitable for the large-scale production of enantioenriched intermediates. In so doing, it is equally a source of information and inspiration for academic research, and, with its contribution by Noble prizewinner W. S. Knowles, will also heighten the status of industrial catalyst specialists working in the exciting field of enantioselective catalysis. Some 25 contributions from top industrial researchers around the world present case studies on the development of the widest possible range of large-scale enantioselective processes, featuring stereoselective production processes of fine-chemicals, agrochemicals and pharmaceuticals. Clearly structured according to the nature of the task, this handbook adopts a problem-driven approach such that readers can easily find how colleagues have dealt with a similar situation.

Dieses Handbuch, herausgegeben von zwei Experten auf ihrem Gebiet, zeigt organischen Chemikern, wie die enantioselektive Katalyse zur Darstellung enantiomerenangereicherter Zwischenprodukte im Industriemaßstab genutzt werden kann. Rund 25 Beiträge (unter anderem von Nobelpreisträger W. S. Knowles) stellen verschiedenste enantioselektive Katalysen in intelligent strukturierter, problemorientierter Weise vor-so lassen sich die Ansätze unmittelbar zur Lösung eigener Fragen anwenden und verallgemeinern!

Asymmetric hydrogenation: The Monsanto L-dopa processThe other l-dopa processThe Chiral Switch of Metolachlor: The Development of a Large Scale Enantioselective Catalytic ProcessAn Innovative Asymmetric Sulfide Oxidation: The Process Development History behind the New Antiulcer Agent EsomeprazoleEnantioselective Hydrogenation: Towards a Large-Scale Total Synthesis of Chiral Terpenoid CompoundsComparison of Four Industrial Syntheses of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate7-Aminocepholasporanic acid - chemical vs. enzymatic production processMethods for the Biocatalytic Production of L-Amino Acids on Industrial ScaleThe large-scale biocatalytic synthesis of enantiopure cyanohydrinsIndustrialization Studies on the Jacobsen Hydrolytic Kinetic Resolution of Racemic EpoxidesScale-up studies in asymmetric transfer hydrogenationPractical Applications on Biocatalysis or the Manufacturing of Chiral alcohols such as (R)-1,3-butanediol by Stereo-specific OxidoreductionMicrobial resolution of 2,3-dichloro-1-propanol and 3-chloro-1,2-propanediolSynthesis of Unnatural Amino AcidsThe Application of DuPHOS Rhodium(I) Catalysts for Commercial Scale Asymmetric Hydrogenation(TMBTP) Ruthenium catalysts: a useful tool for industrial asymmetric hydrogenationsBiocatalytic approaches for large scale production of asymmetric synthonsMaster the scale-up of catalytic asymmetric hydrogenations for the manufacture of fine chemicalsLarge-Scale Applications of Biocatalysis in the Asymmetric Synthesis of Laboratory ChemicalsDevelopment of an Efficient Synthesis of Chiral 2-Hydroxy AcidsFactors Influencing the Application of Literature Methods Toward the Preparation of a Chiral trans-Cyclopropane Carboxylic Acid Intermediate During Development of a Melatonin AgonistHetero Diels-Alder - Biocatalysis Approach for the Synthesis of (S)-3-[2-{(Methylsulfonyl) oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol Methanesulfonate: Successful Application of an Enzyme Resolution ProcessMulti kilo resolution of XU305, a key intermediate to the platelet glycoprotein Iib/IIIa receptor antagonist roxifiban via kinetic and dynamic enzymatic resolutionProtease-Catalyzed Preparation of (S)-2-[(tert-Butylsulfonyl)methyl]-hydrocinnamic Acid for Renin Inhibitor RO0425892Protease-Catalyzed Preparation of Chiral 2-Isobutyl Succinic Acid Derivatives for Collagenase Inhibitor RO0319790Development of a Biocatalytic Process for the Resolution of (R)- and (S)-Ethyl 3-amino-4-pentynoate Isomers Using Enzyme Penicillin acylase