Cell Migration in Development and Disease

Cell Migration matches nearly all research areas in cell and developmental biology, genetics, and biomedicine. The field shows radical progress powered by the combination of new genomic tools, cell labeling techniques and the incorporation of new model systems. This is the first book to comprehensively cover cell migration from the identification of molecular mechanisms to the understanding of certain pathological disorders and cancer development.

Die Zellmigration ist in nahezu allen Bereichen der Entwicklungsbiologie, Genetik und Biomedizin von Bedeutung. Neue Verfahren zur Zellmarkierung und neue Modellsysteme führten zu raschen Fortschritten bei der Erforschung der molekularen Mechanismen der Wanderung von Zellen. Dieser Band handelt alle Aspekte des Themas umfassend ab. Im letzten Kapitel wird die Rolle der Zellmigration bei der Entstehung bestimmter Krankheitsbilder (unter anderem von Tumoren) diskutiert.

Preface (Wedlich)I. CELL SHAPE MODULATIONS AND CELL SURFACE/NUCLEUS CONNECTIONS: PREREQUISITES FOR CELL MIGRATIONFunctional Phases in Cell Attachment and Spreading (Sheetz, Dubin-Thaler, Giannone, Jiang, Döbereiner)Polarised Cell Motility: Microtubules Show the Way (Small, Kaverina)Mechanisms of Eukaryotic Chemotaxis (Janetopoulos, Long, Devreotes)Dual Location Proteins: Communication Between Cell Adhesions and the Nucleus (Cline, Nelson)II. CLASSICAL EXAMPLES OF CELL MIGRATION IN DEVELOPMENTCell Migration During Zebrafish Gastrulation (Castanon, Heisenberg)Aspects of The Origin and Function of Cell Mediolateral Intercalation Behavior (Mib) During Convergent Extension (Keller)On the Border of Understanding Cell Migration (McDonald, Montell)Glia Cell migration in Drosophila (Edenfeld, Klämbt)The Neural Crest: Migrating from the Border (Bronner-Fraser)Primordial Germ Cell Migration in Zebrafish (Raz)HGF/SF c-Met Signaling in Epithelial-Mesenchymal Transition and Migration of Muscle Progenitor Cells (Schaeper, Birchmeier)III. CELL MIGRATION CRUCIAL FOR IMMUNE RESPONSE, WOUND HEALING, AND TUMORIGENESISHost-Pathogen Interactions and Cell Motility: Learning from Bacteria (Stradal, Lommel, Wehland, Rottner)Transendothelial Migration of Leukocytes (Muller, Schenkel)Chemokine-controlled Migration in Lymphoid Organogenesis and the Systemic Organization of Immunity (Lipp)Keratinocyte Migration in Wound Healing (Brakebusch)From Tumorigenesis to Tumor Progression:Signaling Pathways Driving Tumor Invasion and Metastasis (Giehl, Menke, Wedlich, Beil, Seufferlein)