Asymmetric Synthesis in Organophosphorus Chemistry

Authored by one of the leading experts in the field, this is the only comprehensive overview of chiral organophosphorus compounds, from asymmetric synthesis to catalysis and pharmacological applications. As such, this unique reference covers the chemical background as well as spectroscopical analysis of phosphorus compounds, and thoroughly describes all the various synthetic strategies for these substances. Metal-, organo- and biocatalyzed reactions for the introduction of phosphorus are explained as are asymmetric oxidation and reduction methods for the preparation of all possible oxidation states of phosphorus. The text also includes industrial applications for these compounds. Of particular interest to chemists working in the field of asymmetric synthesis, as well as to the pharmaceutical industry due to the increasing number of phosphorous-containing drugs.

Authored by one of the leading experts in the field, this is the only comprehensive overview of chiral organophosphorus compounds, from asymmetric synthesis to catalysis and pharmacological applications.As such, this unique reference covers the chemical background as well as spectroscopical analysis of phosphorus compounds, and thoroughly describes all the various synthetic strategies for these substances. Metal-, organo- and biocatalyzed reactions for the introduction of phosphorus are explained as are asymmetric oxidation and reduction methods for the preparation of all possible oxidation states of phosphorus. The text also includes industrial applications for these compounds.Of particular interest to chemists working in the field of asymmetric synthesis, as well as to the pharmaceutical industry due to the increasing number of phosphorous-containing drugs.

INTRODUCTIONFUNDAMENTALS OF STEREOCHEMISTRY OF ORGANOPHOSPHORUS COMPOUNDSDetermining Enantiomer CompositionDetermining Absolute ConfigurationAsymmetric Induction and StereochemistryASYMMETRIC SYNTHESIS OF P-CHIROGENIC PHOSPHOROUS COMPOUNDSIntroductionLow-Coordinated Organophosphorus CompoundsCompounds of Tervalent Three-Coordinated PhosphorusAsymmetric Induction at P (IV)Enzymatic Synthesis of P-Chiral Phosphorus CompoundsAsymmetric Synthesis of P-Chirogenic P(V) and P(VI)-Phosphorus CompoundsPHOSPHORUS COMPOUNDS WITH CHIRAL CENTRE IN SIDE CHAINIntroductionAsymmetric Reactions in Side Chain of OrganophosphorusEnantioselective OlefinationStereoselective Addition of Phosphoric Nucleophiles to C=X CompoundsAsymmetric ReductionEnantioselective OxidationAsymmetric CycloadditionASYMMETRIC METALLOCOMPLEX CATALYSIS OF PHOSPHORUS COMPOUNDSIntroductionAsymmetric Catalytic Hydrogenation and Reduction ReactionsAsymmetric OxidationElectrophilic Asymmetric CatalysisNucleophilic Asymmetric Catalysis of Addition Reaction to Multiple BondsASYMMETRIC ORGANOCATALYSISIntroductionQuinine and its DerivativesSparteine as a Chirality InductorProline, Amino Acids and their DerivativesVarious ExamplesASYMMETRIC BIOCATALYSIS IN PHOSPHOROUS CHEMISTRYIntroductionEnzymatic Synthesis of Organophosphorus CompoundsMicrobiological Syntheses of Organophosphorus CompoundsCONCLUSION