Systems Biology in Psychiatric Research

Dr. F. Tretter is Senior Physician at the Klinikum München-Haar. He studied Psychology, Medicine and social science with separate doctorates. He worked in experimental electrophysiology for several years at Max Planck Institute for Psychiatry. Later, he worked in clinical psychiatry and specialized in addiction. His present research interests are related to withdrawal syndromes and their treatment, systems research in health care delivery systems, computer simulation of neuronal networks in mental disorders and philosophy of science.Dr. G. Winterer is Professor of Psychiatry at the Psychiatric Clinic, University Düsseldorf, and scientific coordinator of DFG research program : "Nicotine: molecular and physiological effects in the central nervous system of humans ".Dr. P. Gebicke-Haerter is Head of the Molecular Biology /DNA Chip Facility in theDept. of Psychopharmacology at Central Institute of Mental Health, Mannheim.He started his career at the University of Göttingen and the Max-Planck-Institute there, went as a post-doc fellow to Stanford University, Dept. of Neurobiology, and then became a group leader in the Dept. of Pharmacology at the University of Freiburg. After his habilitation, he switched to the Clinic for Psychiatry in Freiburg and in 2000 went to the Central Institute of Mental Health in Mannheim. His CV contains almost 100 original publications, various reviews and/or book chapters.

Hochaktuelle Fortschritte auf diesem noch jungen Forschungsgebiet werden hier erstmals in Buchform zusammengefasst. Die Beiträge stammen aus verschiedenen Disziplinen, wobei Schwerpunkte auf Hochdurchsatz-Methoden und Algorithmen zur Datenanalyse liegen. Es wird vorgeführt, wie Experimente in silico Aufschlüsse über komplexe biologische Vorgänge in neuronalen Systemen liefern können.

- First title on an emerging topic which will decisively influence psychiatric research.

- Written by leading experts and following a multidisciplinary approach.

- Wide audience including advanced students, pharmaceutical companies and clinical researchers.

INTRODUCTIONPhilosophical Aspects of Neuropsychiatry (Tretter)Neuropsychiatry - Subject, Concepts, Methods and Computational Models (Tretter, Gebicke-Haerter)Introduction to Systems Biology (Schulz, Klipp)Mind over Molecule: Systems Biology for Neuroscience and Psychiatry (Noble)BASICSNeuropsychiatry, Psychopathology and Nosology - Symptoms, Syndromes and Endophenotypes (Kawohl, Hoff)System Properties of Populations of Neurons in Cerebral Cortex (Freeman)Dopamine and the Electrophysiology of Prefrontal Cortical Networks (O'Donnell)RESEARCH IN MOLECULAR PSYCHIATRYNicotinic, Cholinergic Signaling in the Human Brain - Systems Perspective (Mobascher, Winterer)Progress in Psychopharmacotherapy through Molecular Imaging (Vernaleken, Gründer, Cumming)The Marriage of Phenomics and Genetical Genomics: A Systems Approach to Complex Trait Analysis (Saba, Hoffman, Hunter, Tabakoff)DATA MINING AND MODELINGFrom Communicational to Computational: Systems Modeling Approaches for Psychiatric Research (Mendoza)Network Dynamics as an Interface between Modelling and Experiment in Systems Biology (Smith, Hütt)Some Useful Mathematical Tools to Transform Microarray Data into Interactive Molecular Networks (Matthäus, Smith, Gebicke-Haerter)Biochemical Networks in psychiatric disease (Lindskog, Halnes, Oliveira, Hellgren Kotaleski, Blackwell)Local Cortical Dynamics Related to Mental Illnesses (Loh, Rolls, Deco)Epilogue (Gebicke-Haerter)