Intracellular Niches of Microbes

Ulrich Schaible is Professor of Immunology at London School of Hygiene & Tropical Medicine, UK. After graduating from Freiburg University, he obtained his PhD working with Marcus Simon at the Max-Planck-Institute of Immunobiology, Freiburg. After a postdoc with David Russell at Washington University, St. Louis, USA, he joined the department of Stefan Kaufmann at the Max-Planck-Institute of Infection Biology, Berlin. He combines immunology and cellular microbiology to study host-pathogen-interactions in tuberculosis. He has authored 86 articles and received the Royal Society Wolfsohn Research Merit Award, the GlaxoSmithKline-Foundation for Clinical-Research-Award and the Otto-Westphal-Award of the German Society of Immunology.Albert Haas was appointed Professor of Cell Biology at Bonn University in 2001. After graduating from Würzburg University, he obtained his PhD in Microbiology working with Werner Goebel on Listeria pathogenesis. After postdoctoral research in Bill Wickner's lab at UCLA (Los Angeles, CA) and Dartmouth College (Hanover, NH) on yeast cell biology, he returned to Würzburg University to start his independent research which focuses on questions of phagosome biogenesis. He has authored 35 articles and received the Vector-Laboratories Young Investigator Award (American Society for Microbiology), the Butenandt-Habilitation-Award and the Karl-Lohmann-Award, both from the German Society for Biochemistry and Molecular Biology.

The book describes the different and exciting pathways which have been developed by pathogenic microbes to manage living inside host cells. It covers intracellular life styles of all relevant pathogenic but also symbiotic microorganisms with respect to the cell biology of the host-microbe interactions and the microbial adaptations for intracellular survival. It features intracellular trafficking pathways and characteristics of intracellular niches of individual microbes. The book also asks questions on the benefits for the microbe with regard to physiological needs and nutritional aspects such as auxotrophy, effects on genome sizes, and consequences for disease and host response/immunity (and the benefits for the host in the cases of symbionts).

Additionally, the book includes those pathogens that are medically less important but represent distinct intracellular niches, trafficking behaviours and virulence traits. The individual chapters also point out future challenges of research for the respective organism.

Providing information from general mechanisms to microbe specific phenomena,most excellent specialsist in the field guide us through microbes niches within a host cell. In a unique style the book reviews microbes adaptation as result of long lasting evolutionary processes.

Foreword (Sansonetti)GENERAL ASPECTSIntroduction: The Evolution of Intracellular Life Forms and their Niches (Schaible and Haas)Limited Genomes and Gene Transfer in the Evolution of Intracellular Parasitism and Symbiosis (Somboonna and Dean)Phagocytosis: Early Events in Particle Recognition and Uptake (Cosío and Grinstein)Cellular Model Systems Used to Study Phagosome Biogenesis (Steinert)Methods Used to Study Phagosome Biogenesis (Haas)In Vitro Fusion Assays with Phagosomes (Becken and Haas)Phagosome Proteomes Unite! A Virtual Model of Maturation as a Tool to Study Pathogen-Induced Changes (Dieckmann and Soldati)Phagosome - Cytoskeleton Interactions (Gutierrez and Griffiths)Intracellular Microbe Whole-Genome Expression Profiling: Methodological Considerations and Biological Inferences (Waddell and Butcher)Everybody Has A Home of Their Own - The Phagosome Zoo (Haas)Consequences of Pathogen Compartmentation for Therapeutic Intervention (Haas and Schaible)The Immune Response to Intracellular Pathogens (Korbel and Schaible)SELECTED PATHOGENSVACUOLAR BACTERIAAfipia felis (Schneider and Haas)Brucella (Kalde, Moreno, and Gorvel)Chlamydiae (Hackstadt)Coxiella burnetii (Gilk, Voth, and Heinzen)Ehrlichia and Anaplasma (Rikihisa)Legionella pneumophila (Ingmundson and Roy)Mycobacterium tuberculosis and His Comrades (Schaible)Rhodococcus equi and Nocardia asteroides (von Bargen and Haas)Salmonella (Steele-Mortimer)INTRACYTOSOLIC BACTERIABurkholderia pseudomallei (Stevens and Stevens)Francisella tularensis (Allen and Schulert)Listeria monocytogenes (Balestrino and Cossart)Mycobacterium marinum (Hagedorn and Soldati)Rickettsia (Sahni, Rydkina, and Silverman)Shigella (Van Nhieu and Sansonetti)INTRACELLULAR SYMBIONTSBacterial Symbionts of Plants (Kambara, Broughton, and Deakin)Cyanobacterial and Algal Symbioses (Kovacevic, Steiner, and Löffelhardt)Insect Symbionts (Feldhaar and Gross)PARASITES AND FUNGIHistoplasma capsulatum (Newman)Leishmania: L. mexicana vs. donovani vs. major; Amastigotes vs. Promastigotes (Matte, Mallégol, and Descoteaux)Plasmodium and Babesia (Winterberg, Przyborski, Lingelbach)Theileria (Dobbelaere and Baumgartner)Toxoplasma gondii (Sibley)Trypanosoma cruzi (Taylor)Trichinella and the Nurse Cell (Guiliano and Oksov)