Management of Infections in the Immunocompromised Host

Dr. Brahm Segal is currently the Vice Chair of Faculty Development at the University of Buffalo School of Medicine and Chief of the Division of Infectious Diseases at Roswell Park Cancer Institute. He earned his medical degree at Albert Einstein College of Medicine before completing his residency at Tufts New England Medical Center. He completed a fewllowship in infectious diseases at the National Institute for Allergy and Infectious Diseases and has dedicated himself to treating patients, lecturing, educating clinical trainees, and researching host defenses through his nationally funded translational research program. Dr. Segal has been honored with a multitude of awards, including Best Doctor and Top Doctor in 2011.

This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research. This book begins with an overview of the normally functioning immune system followed by a detailed discussion of the major primary immunodeficiencies. Specific chapters are dedicated to providing practical knowledge in the prevention and treatment of infections in specific immunocompromised patients, including those with cancer, transplant recipients, HIV infection, and autoimmune disorders. Emphasis is placed on diagnostic evaluation, antimicrobial selection that includes consideration of the threat of antimicrobial-resistant pathogens, and immunotherapy tailored to specific patients. Finally, dedicated chapters on stem cell transplantation for patients with primary immunodeficiencies,adoptive cellular immunotherapy, and gene therapy will provide readers with insight into these rapidly evolving and cutting edge therapies.Management of Infections in the Immunocompromised Host is a valuable resource for infectious diseases specialists, immunologists, oncologists, hematologists, general physicians, students, researchers, and all other working with immunocompromised patients.

¿Comprehensive in scope

1.Phagocytes.- 2.T-cells.- 3.B cell Immunity.- 4.Complement.- 5.Antimicrobial peptides.- 6.Role of Deficits in Pathogen Recognition Receptors in Infection Susceptibility.- 7.Defects of Innate Immunity.- 8.T Cell Defects.- 9.Inflammatory Bowel Disease in Primary Immunodeficiencies.- 10.Infections in Cancer.-  11.Infections in Hematopoietic Stem Cell Transplant Recipients.- 12.Infections in Solid Organ Transplant Recipients.- 13.Infections in HIV infected patients.- 14.Infections in Patients with Autoimmune Diseases.- 15.Antibacterials and antifungals: The Challenges of Antibiotic-Resistant Infections in the Immunocompromised Host.- 16.Antiviral treatment and prophylaxis in immunocompromised hosts.- 17.Role of Immunoglobulin Therapy to Prevent and Treat Infections.- 18.Vaccination of Immunocompromised Patients.- 19..Stem Cell Transplantation for Primary Immunodeficiency.- 20.Specific Adoptive T-cell Therapy for Viral and Fungal Infections.- 21.Gene Therapy for Primary Immunodeficiencies.