Beschreibung:
Dr. Olga A. Smirnova is a physicist and researcher at the Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, Moscow, Russia. She uses the framework of developed deterministic mathematical models to investigate the effects of both acute and chronic irradiation in a wide range of doses and dose rates on vital body systems, including hematopoiesis, small intestine and humoral immunity, as well as on the development of autoimmune diseases. Dr. Smirnova's fields of study and expertise include modeling the dynamics of various biological systems in mammals exposed to acute/chronic radiation.
Dr. Smirnova's updated text is devoted to the theoretical studies of radiation effects on mammals. It summarizes 35 years of results the author obtained from analyzing dose rate equivalents for the Galactic Cosmic Rays (GCR) and for Solar Particles Events (SPE). This edition also includes two new chapters on skin epidermal epithelium and risk assessment for myeloid leukemia, as well as extended revisions addressing the radiation effects on the blood-forming system. Mathematical models are used to explain the effects of both acute and chronic irradiation on the dynamics of vital body systems, like the hematopoietic system, the development of autoimmune diseases, and the mortality dynamics in homogeneous and nonhomogeneous mammalian populations. The proposed methodology of these studies, the models themselves, and the obtained results are of a great theoretical significance and canfind wide practical use.
Studies fundamental problems in radiation biology (namely, acute/chronic effects of irradiation from exposure such as in the space environment on vital body systems, on whole organisms, and on mammalian populations) using mathematical modeling
Effects of Acute and Chronic Irradiation on the Blood-Forming System.- Effects of Non-Uniform Acute Irradiation on the Blood-Forming System. - The Small Intestine as a Target for Radiation.- Radiation and Humoral Immunity.- Modeling of Autoimmune Processes.- Individual-Based Approach to Risk Assessment of Radiation-Induced Mortality.- Effects of Acute and Chronic Irradiation on Human Hematopoiesis. - Radiogenic Leukemia Risk Assessment. - Radiation and Skin. - Conclusions.- Index.
