Beschreibung:
This book offers a comprehensive overview of the state of the art in the practice of radioguided surgery. The opening section is devoted to the basic physics principles for detection and imaging, radiation detection device technology, principles of surgical navigation, radionuclides and radiopharmaceuticals, and radiation safety. A series of chapters then address the clinical application of radioguided surgery for a variety of malignancies, including breast cancer, melanoma and other cutaneous malignancies, gynecologic malignancies, head and neck malignancies, thyroid cancer, urologic malignancies, colon cancer, gastroesophageal cancer, lung cancer, bone tumors, parathyroid adenomas, and neuroendocrine tumors. For each application, the recommended methodological approaches are discussed and the available cumulative clinical experiences of investigators from across the globe are reviewed. A conscious effort is made to highlight recent developments and innovative multidisciplinary approaches within each clinical area. Interesting issues and novel approaches are further explored through a collection of selected case reports at the end of the book. The contributing authors are all experts in their own fields, ensuring that the book will hold wide appeal for surgeons, surgical technologists, nuclear medicine physicians, nuclear medicine technologists, and various trainees.
This book offers a comprehensive overview of the state of the art in the practice of radioguided surgery. The opening section is devoted to the basic physics principles for detection and imaging, radiation detection device technology, principles of surgical navigation, radionuclides and radiopharmaceuticals, and radiation safety. A series of chapters then address the clinical application of radioguided surgery for a variety of malignancies, including breast cancer, melanoma and other cutaneous malignancies, gynecologic malignancies, head and neck malignancies, thyroid cancer, urologic malignancies, colon cancer, gastroesophageal cancer, lung cancer, bone tumors, parathyroid adenomas, and neuroendocrine tumors. For each application, the recommended methodological approaches are discussed and the available cumulative clinical experiences of investigators from across the globe are reviewed. A conscious effort is made to highlight recent developments and innovative multidisciplinary approaches within each clinical area. Interesting issues and novel approaches are further explored through a collection of selected case reports at the end of the book. The contributing authors are all experts in their own fields, ensuring that the book will hold wide appeal for surgeons, surgical technologists, nuclear medicine physicians, nuclear medicine technologists, and various trainees.
Part 1 Introduction.- The History of Radioguided Surgery: Early Historical Milestones and the Development of Later Innovative Clinical Applications.- Part 2 Detailed Methodology Part.- Physics of Radioguided Surgery.- The use of intraoperative small and large field of view gamma cameras for radioguided surgery.- Surgical Navigation.- Tracers applied in radioguided surgery.- Radiation Safety and Dosimetry.- Part 3 Clinical Application: Breast.- Radioguided sentinel lymph node mapping and biopsy in breast cancer.- Radioguided Surgery for Non-Palpable Breast Lesions: I-125 Radioactive Seed Localization.- Radioguided Surgery for Non-Palpable Breast Lesions: Technetium-99m Radioguided Occult Lesion Localization (ROLL).- Part 4 Clinical Application: Skin.- Radioguided sentinel lymph node mapping and biopsy in cutaneous melanoma.- Part 5 Clinical Application: Head and Neck.- Sentinel lymph node mapping and biopsy in oral cancer.- Part 6 Clinical Application: Thyroid and Parathyroid.- Radioguided sentinel lymph node mapping and biopsy in thyroid cancer.- Radioguided Parathyroid Surgery.- Radioguided surgery of thyroid carcinoma recurrences.- Part 7 Clinical Application: Urogenital Tract.- Radioguided sentinel lymph node biopsy and lymphatic mapping in urogenital malignancies.- Radioguided sentinel lymph node mapping and biopsy in Gynaecological malignancies .- Part 8 Clinical Application: Gastrointestinal Tract.- Radioguided sentinel lymph node mapping and biopsy in oesophago-gastric.- Radioguided sentinel lymph node mapping and biopsy in colorectal cancer.- Radioguided surgery in gastro-entero-pancreatic neuroendocrine tumors.- Part 9 Clinical Application: Thoracic.- Radioguided sentinel lymph node mapping and biopsy in non-small-cell lung cancer (NSCLC).- Radioguided surgery of small pulmonary nodules.- Part 10 Miscellaneous.- Radioguided localization of bone lesions.- Radioguided monitoring of systemic leakage during isolated limb perfusion.- Radioimmunoguided Surgery:Intraoperative radioimmunodetection for the radioguided localization and resection of tumors.- 18F-FDG-Directed Surgery and 18F-FDG-Directed Interventional Procedures.- Part 11 Outlook: New techniques, image fusion, optical imaging.- Fluorescent tracers, hybrid tracers.- Magnetic Advances in Cancer Surgery.- Ultrasound fusion.- Part 12 Examples (conventional techniques and innovations).
