Non-Vitamin K Antagonist Oral Anticoagulants

1. Introduction

1.1 Overview of the coagulation cascade.

1.2 Current approaches to anticoagulation

1.3 The ideal anticoagulant

References

2.  Direct thrombin inhibitors.

2.1 Historical excursus: ximelagatran

2.2 Dabigatran etexilate

2.2.1 Venous thromboembolism prevention in major orthopedic surgery

2.2.2 Venous thromboembolism treatment

2.2.4 Other directions

References

3. Factor Xa inhibitors

3.1 Rivaroxaban

3.1.1 Venous thromboembolism prevention following joint surgery

3.1.2 Treatment of venous thromboembolism

3.1.3 Stroke prevention in atrial fibrillation

3.1.4 Acute coronary syndromes

3.2 Apixaban

3.2.1 Venous thromboembolism prevention in major orthopedic surgery

3.2.2 Stroke prevention in atrial fibrillation 

3.2.3 Thromboprophylaxis in other clinical settings

3.2.5 Acute coronary syndrome

3.3 Edoxa

3.3.1 Venous thromboembolism prevention in major orthopedic surgery

3.3.3 Treatment of venous thromb

3.4 Emerging

3.4.1 Betrixaban

References

4.Conclusions

4.1 Future directions

References