Genomics, Personalized Medicine and Oral Disease

The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral micro biome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.

The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral micro biome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.

Fundamentals of genetics, genomics, and personalized medicine.- Current and evolving genomic-based technologies. The oral micro biome, translational genomics and personalized medicine: the future.- Host genetics and response to Herpes simplex type I infection.- Orofacial clefts: the promise of personalized medicine for developmental anomalies.- Genetics and genomic studies of dental caries: insights into the promise of personalized medicine.- Periodontal disease.- Recurrent aphthous stomatitis puzzle in the era of the omic technologies.- Genomics and bioinformatics of oral lichen planus (OLP).- Pemphigoid disease.- Salivary gland diseases.- Insights into oral epithelial premalignancy from the genetic/epigenetic viewpoints.- Oral cancer.- Medication-induced osteonecrosis of the jaw (MIONJ).- Developing a gene therapy for radiation-induced dry mouth.- Radiation protection of the oral cavity/oropharynx: antioxidant strategies from MnSOD-plasmid liposomes to GS-nitroxides.- Pharmacogenomics and oral diseases.- Genetically modifiedLactococcus lactis: a novel engineering system for mucosal delivery.- Personalized medicine, genomics and oral diseases: the future.