This book covers both the technological development and biomedical applications of NADH fluorescence. Topics covered include perspectives on the history of monitoring NADH fluorescence, the relationship between mitochondrial function and other functions at the tissue level, responses of NADH to physiological and pathophysiological conditions, monitoring of NADH in the human brain and other organs, and metabolism. It also includes an in-depth look at flavoprotein (Fp) fluorescence and NADH in relation to redox state. This is an ideal book for biomedical engineers, researchers, and graduate students interested in learning the biomedical applications of NADH fluorescence.
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About the Author
Avraham Mayevsky, Ph.D. is a Professor Emeritus in theFaculty of Life Sciences and the Brain Research Center at Bar Ilan University, Israel.
He has published more than two hundred papers in the field of mitochondrial function and tissue physiology in vivo under pathophysiological conditions.
1. Introduction.- 2. Tissue Energy Metabolism and Mitochondrial Function.- 3. Spectroscopic monitoring of NADH – Historical Overview.- 4. Technological aspects of NADH monitoring In Vivo.- 5. Monitoring of NADH together with other tissue physiological parameters.- 6. Multisite Monitoring of NADH.- 7. Responses of NADH to physiological and pathophysiological conditions.- 8. Monitoring of various organs in various animal models.- 9. Monitoring of NADH in Human brain and body organs.- 10. Discussion.- Index.