Targeted Drug Delivery : Concepts and Design

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

1 Targeted Drug Delivery Systems – Strategies and Challenges.- 2 Recent Advances in Tumor Targeting Approaches.- 3 Infectious Diseases: Need for Targeted Drug Delivery.- 4 Image-Guided Delivery of Therapeutics to the Brain.- 5 Inhalation Therapy for Pulmonary Tuberculosis   .- 6 Hepatic Targeting: Physiological Basis and Design Strategy.- 7 Targeted Drug Delivery to the Mitochondria.- 8 Targeted Delivery of Nucleic Acid Therapeutics via Non-viral Vectors.- 9 Mucosal Vaccine Delivery and M Cell Targeting.- 10 Stimuli responsive carriers: Magnetically, Thermal and pH Assisted Drug Delivery.- 11 Prodrug Conjugate Strategies for Targeted Anticancer Drug Delivery Systems.- 12 Polymer-Drug Conjugates for Targeted Drug Delivery.- 13 Functionalized Lipid Particulates in Targeted Drug Delivery.- 14 Nanoemulsions in Drug Targeting.- 15 Multifunctional Polymeric Nano-Carriers in Targeted Drug Delivery.- 16 Polymeric Micelles in Targeted Drug Delivery.- 17 Dendritic Polymers in Targeted Drug Delivery.- 18 Inorganic Nanoparticles in Targeted Drug Delivery and Imaging.- 19 Carbon-based Nanomaterials for Targeted Drug Delivery and Imaging.- 20 Physical and Biophysical Characteristics of Nanoparticles: Potential Impact on Targeted Drug Delivery.- 21 In Vivo Imaging Techniques of the Nanocarriers used for Targeted Drug Delivery.- 22 Evaluation of Lung Toxicity of Biodegradable Nanoparticles.- 23 Nanotoxicology: Contemporary Issues and Future Directions.