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Autor: Kimberly Geoghegan
ISBN-13: 9783319103389
Einband: eBook
Seiten: 151
Sprache: Englisch
eBook Typ: PDF
eBook Format: eBook
Kopierschutz: Adobe DRM [Hard-DRM]
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Selectivity in the Synthesis of Cyclic Sulfonamides

Springer Theses
Application in the Synthesis of Natural Products
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In the area of organic chemistry one major challenge we are currently faced with is how to assemble potentially useful molecules in new ways that generate molecular complexity and in sequences that are as efficient as possible. Our efforts in this regard, specifically for the preparation of amino containing compounds incorporating an aromatic ring, are described in this doctoral thesis. We discovered an interesting regioselectivity in an intramolecular Heck reaction, which we studied for a series of substrates that are unbiased in terms of the size of the newly formed ring, where very high levels of selectivity in relation to the new carbon-carbon bond are typically observed. DFT calculations were performed to attempt to shed light on the reaction sequence. This regioselective Heck reaction, combined with the reductive removal of the temporary amino-protecting group, allowed us to synthesize the Sceletium alkaloids: mesembrane, mesembranol and mesembrine.
Introduction.- Regioselectivity in the Heck (Mizoroki-Heck) Reaction.- Wagner-Meerwein Rearrangement of Cyclic Sulfonamides.- An Investigation into the One-Pot Heck Olefination-Hydrogenation Reaction.- Double Reduction of Cyclic Aromatic Sulfonamides.- Experimental.- Appendix.

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Autor: Kimberly Geoghegan
ISBN-13 :: 9783319103389
ISBN: 3319103385
Verlag: Springer International Publishing
Seiten: 151
Sprache: Englisch
Auflage 2014
Sonstiges: Ebook