Philip Kocienski was born in Troy, New York in 1946. His love for organic chemistry, amply stimulated by Alfred Viola whilst an undergraduate at Northeastern University, was further developed at Brown University, where he obtained his PhD degree in 1971 under Joseph Ciabattoni. Postdoctoral study with George Büchi at MIT and later with Basil Lythgoe at Leeds University in England, confirmed his interest in the synthesis of natural products. He was appointed Brotherton Research Lecturer at Leeds in 1979 and Professor of Chemistry at Southampton University in 1985. He moved to the University of Glasgow in 1997 as Regius Professor of Chemistry. In 2000 he returned to Leeds as Professor of Organic Chemistry.
Protecting Groups is an invaluable survey of the most widely used protecting groups. It provides a critical survey of protecting group methodology and focuses on the most widely used protecting groups for the most common functional groups. Therefore it serves as an essential learning tool for advanced students and professionals in a broad range of disciplines involving organic synthesis.
Protecting Groups is organized by functional group and places special emphasis on deprotection conditions applied to complex structures where selectivity is a key issue. The discussion of each protecting group is divided into three sections beginning with deprotection conditions, followed by methods of formation, and ending with some characteristic NMR data to aid the reader in identifying the contribution from the protecting group. At the end of each chapter is a list of reviews for the topics covered in that chapter.
Features of the Third Edition:
- Focuses on a relatively small number of commonly used protecting groups
- Places emphasis on deprotection conditions
- Uses schemes extensively
- Has been reorganised and thoroughly revised and updated
- Two new chapters on thiol and phosphate protecting groups have been added
- The number of schemes has increased from 500 to 1200
- Colour has been introduced as an aid to visual retrieval
- The number of references has increased from 1200 to 2270 with emphasis given to literature covering the period 1990-2001
Table of Contents Chapter 1:Protecting Groups: An Overview Chapter 2:Carbonyl Protecting Groups Chapter 3:Diol Protecting Groups Chapter 4:Hydroxyl Protecting Groups Chapter 5:Thiol Protecting Groups Chapter 6:Carboxyl Protecting Groups Chapter 7:Phosphate Protecting Groups Chapter 8:Amino Protecting Groups