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Cancer Biomarkers: The Urokinase Plasminogen Activator System
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Molecular Mechanisms and Clinical Relevance
Besorgungstitel - wird vorgemerkt | Lieferzeit: Besorgungstitel - Lieferbar innerhalb von 10 Werktagen I
Artikel-Nr:
9783110283396
Veröffentl:
2020
Seiten:
460
Autor:
Manfred Schmitt
Format:
240x170x36 mm
Sprache:
Englisch
Beschreibung:
John A. Foekens, Erasmus Medical Center, Rotterdam, Netherlands; Fred Sweep, Radboud University Nijmegen, Netherlands; Nadia Harbeck, Ludwig-Maximilians-University, Munich, Germany; Nils Brünner, University Kopenhagen, Denmark; Manfred Schmitt,Technical University Munich, Germany.
The serine protease urokinase-type plasminogen activator, its inhibitor and its receptor are considered the most valuable prognostic cancer biomarkers relevant to predict the clinical course of cancer patients and their response to cancer therapy. They are also among the few biomarkers that have been evaluated successfully in clinical studies for their clinical utility, for the most part in early breast cancer. This work provides an overview of the molecular mechanisms and clinical outlook of this important proteolytic system.