Neuroimmune Diseases

Mario Manto, MD, PhD, is Neurologist, Head of the Department of Neurology at the CHU-Charleroi, Professor of Neuroanatomy and Neurological Semiology at the University of Mons. He is also teaching Pathophysiology of the Nervous System. He is the Founding Editor of The Cerebellum, Cerebellum and Ataxias and has written or edited 10 books.

Fundamental mechanisms and general principles.- Overview of mechanisms underlying neuroimmune diseases.- Principles in effecter T cells.- The roles of Th17 Cells in immunopathogenesis of neuroinflammatory disorders.- Significance of autoantibodies.- Immune tolerance in autoimmune central nervous system disorders.- The roles of regulatory T cells in central nervous system autoimmunity.- Disruption of the blood-brain barrier during neuroinflammatory and neuroinfectious diseases.- Structural and functional characteristics of the human blood-nerve barrier with translational implications to peripheral nerve autoimmune disorders.- Multi-actions of microglia.- Autoimmune astropathy.- The intestinal neuro-immune axis.- Genetic factors in neuroimmune diseases.- General principles of immunotherapy in neurological diseases.- Tageted therapies  - Disorders : diagnosis and therapies.- Post-infectious immune mediated neurological diseases.- SARS-Cov2-mediated-neuroinflammation.- Vaccine-induced  thrombotic thrombocytopenia related to COVID-19 vaccination.- Paraneoplastic neurological syndromes.- Multiple sclerosis.- Neuromyelitis optica spectrum disorder.-  Atypical inflammatory demyelinating syndromes of the central nervous system.- GFAP astrocytopathy.- Central nervous system vasculitis .- Autoimmune Limbic encephalitis.- Rasmussen encephalitis.- Autoimmune ataxia.- Stiff-Person Syndrome Spectrum Disorders.- Sjögren's syndrome and neuroinflammation.- Behçet's syndrome and the nervous system involvement.- Neurosarcoidosis.- Uveomeningitis.- Anti-IgLON5  syndrome: a cross talk between autoimmune and taupathgy.- Neuroinflammation in Alzheimer' s disease.- Neuroinflammation in Parkinson's disease.- Guillain-Barré syndrome.- Chronic inflammatory demyelinating polyneuropathy.- Myasthenia gravis and other Immune-mediated disorders ofthe neuromuscular junction.- Myositis.