Skin and the Heart

This book describes the relationship of the skin with cardiovascular disease. It details the variety of genetic, autoimmune, metabolic and endocrine factors that link the two disciplines. Recognition of one sign or symptom in dermatology can lead to the investigation and discovery of an important related cardiac condition, the recognition of which is important to prevent cardiovascular complications. Similarly, a cardiac condition may be related to an underlying skin condition that requires treatment.

Genetic examples of such instances included within the book include: pseudoxanthoma elasticum, epidermolysis bullosa with desmosome defects and plectin defects; Marfan syndrome; Autoimmune conditions include vasculitis, sarcoidosis, lupus; metabolic conditions include insulin resistance,  eruptive xanthomas with hypertriglyceridemias and elevated cholesterol; endocrine disorders include thyroid acropachy with atrial fibrillation; insulin resistance with coronary artery disease and psoriasis or hidradenitis suppurativa.

Skin and the Heart reviews the effects of genetic, autoimmune and endocrine diseases with connections between skin and heart. It is therefore a key reference for all practitioners and researchers working in both disciplines.

Preface.- I. Embriology.- 1. Embryology of the skin.- 2. Embryology of the heart.- II. Genetic diseases.- 3. Epidermolysis bullosa.- 4. Cutaneous Manifestations of Aortic Disease.- 5. Tuberous Sclerosis Complex: Skin and Heart: Pivotal Common and Early Signs.- 6. Incontinentia pigmenti.- 7. The Heart in Neurofibromatosis.- 8. Cardiocutaneous desmosomal disorders SEE II.2.- III. Inflammatory diseases.- 9. Lupus erythematosus and other collagen diseases.- 10. Vasculitis.- 11. Behçet’s Disease.- 12. Kawasaki disease.- IV. Infectious.- 13. COVID-19.- 14. Lyme disease.- 15. Syphillis.- 16. Viral conditions (varicella, congenital rubella).- V. Metabolic and endocrine diseases.- 17. Xanthomas and abnormalities of lipid metabolism and storage.- 18. Diabetes mellitus.- 19. Lysosomal Storage Disorders – Fabry Disease.- 20. Mastocytosis.- VI. Drug reaction.- 21. Cardiotoxic and skin rections inducing medication.- 22. Cardiovascular side effects of skin diseases treating medication.- 23. The importance of cardiac assessment in the era of biologic therapies for psoriasis.- VII. Erythoroderma (ex. High output cardiac failure – erythroderma, etc).- 24. Erythroderma and cardiac function.- VIII. Miscellaneous.- 25. Disorders of fluid regulation.- 26. Infantile hemangiomas and the heart.- 27. Erdheim Chester disease.- 28. Cardiac Implantable Device Related Complications.- Index.