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Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers
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Artikel-Nr:
9783030484057
Veröffentl:
2020
Einband:
eBook
Seiten:
340
Autor:
Ganji Purnachandra Nagaraju
eBook Typ:
PDF
eBook Format:
Reflowable eBook
Kopierschutz:
Digital Watermark [Social-DRM]
Sprache:
Englisch
Beschreibung:
Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor's increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance.To circumvent these difficulties, drug therapy targeting the tumor's specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance.
To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
Introduction
- Current dilemmas in the treatment of GI and liver cancers
- Chemoradioresistance in GI Cancers
- Tumor microenvironment against the action of chemotherapeutic drugs in GI cancer therapy
- Role of phytochemicals on growth and metastasis of GI cancers
- Combination of phytochemicals with chemotherapy on GI cancers cell death
- Phytochemicals plus checkpoint inhibitors in GI cancers
- Phytochemical analogues for the advancement of fourth generation therapeutic drugs for GI cancers
- Phytochemicals on exosomes in GI cancers
- The role of preventitive medicine and personalized care in overcoming cancer resistance and metastasis of GI cancers
- Cancer stem cells as therapeutic targets for GI and liver cancers
- Combination of phytochemicals with nanotechnology for targeting GI cancer therapy