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Cellular Nanomachines
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From Discovery to Structure-Function and Therapeutic Applications
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Artikel-Nr:
9783030444952
Veröffentl:
2020
Einband:
HC runder Rücken kaschiert
Erscheinungsdatum:
30.04.2020
Seiten:
128
Autor:
Bhanu P. Jena
Gewicht:
366 g
Format:
241x160x13 mm
Sprache:
Englisch
Beschreibung:
Bhanu P. Jena is George E. Palade University Professor & Distinguished Professor of Physiology at Wayne State University School of Medicine, and Director of the NanoBioScience Institute. In 1996 while an Assistant Professor at Yale University School of Medicine, he discovered the 'porosome', a new cellular nanomachine that serves as the secretory portal in cells. Prof. Jena is the recipient of numerous awards and honours, among them six honorary doctorates, the Aaron Klug Award, Palade Gold Medal, and AAAS Fellow. He received his Ph.D. from Iowa State University followed by postdoctoral training as a Swebilius Fellow at Yale University.
In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them. The major focus of this book is the "porosome" nanomachine, the universal secretory portal in cells. This is an ideal book for students, researchers, and professionals in the fields of nanoscience and nanotechnology.
Illustrates the structure, isolation, composition, and the functional reconstitution of the porosomes nanomachine: cells' secretory portal
Introduction.- Porosome: Cells Secretory Nanomachine.- Ubiquitin-Proteasome Machinery: Cells Garbage Disposal.- Chaperonin: Protein Folding Machinery in Cells.- ATP Synthase: Energy Generator of the Cell.- Ribosome: Cells Protein Synthetic Machinery.- Nuclear Pore: A Bidirectional Transport Machinery.- Myosin: Cellular Molecular Motor.- Assembly of Cellular Nanomachines. Index.