Polysaccharides of Microbial Origin

Dr. Joaquim Miguel Oliveira (0000-0001-7052-8837),BSc, PhD, is a Portuguese Principal Investigator with Habilitation who has focused his work on the field of biomaterials for tissue engineering, nanomedicine, stem cells, and cell/drug delivery (3bs.uminho.pt/users/ migueloliveira). Since December 2018, he is VicePresident of I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of the University of Minho. He is also Director of Pre-clinical Research at the FIFA Medical Center, Estádio do Dragão, Porto, PT, since February 2013. Currently, he is a lecturer in Doctoral Program in Tissue Engineering, Regenerative Medicine and Stem Cells (TERM&SC) at UMinho, PT (since December 2013). He is also an invited lecturer at the Faculty of Medicine, U. Porto (since September 2013) and Department of Polymer Engineering, UM, PT (2009-present). Recently, he has been nominated for integrating the National Ethics Committee for Clinical Research (CEIC), Serviço Nacional de Saúde (SNS), Portugal, for the period of 2020-2023. He has been awarded several prizes including the prestigious Jean Leray Award 2015 from the European Society for Biomaterials for Young Scientists for Outstanding Contributions within the field of Biomaterials. In addition, he is member of the advisory board of the Journal of Materials Science: Materials in Medicine, International Journal of Tissue Engineering, Journal ISRN Biomaterials, the Journal of Experimental Orthopaedics, and one of the Editors-in-chief of In vitro Models (Springer), and is referee in more than 40 international journals. As result of his proficiency (as of November 2021), Dr. Oliveira has published more than 470 scientific contributions in scientific journals with referee (some in xiii high impact factor journals), 16 of those papers produced under invitation. Dr. Miguel Oliveira is inventor of 22 patents and published 10 books (+3 in preparation), 9 special issues/topical collections in scientific journals, 124 book chapters in books with international circulation, in international encyclopaedias, and science dissemination. He has great experience in intellectual property rights and patent exploitation. He has participated in more than 630 communications in national/ international conferences. Due to his expertise, he participated as invited/keynote speaker in more than 77 plenary sessions. He made great contributions in the osteochondral field, namely by proposing bilayered scaffolds, work that has been highly cited by its peers. Dr. Miguel Oliveira (as of November 2021) has an h-index of 54, i10 of 183, and received more than 10,700 citations (Google Scholar), or an h-index of 45 and ~7710 total citations (Scopus). He has an RG46.09 (ResearchGate).

This book provides a comprehensive analysis of microbial polysaccharides, their current uses, and highlights biomedical opportunities. The topics comprise principally a) their extraction, isolation, purification and advanced production processes; b) characterization of their structural, physicochemical, and biological properties, among others, by several techniques; c) description of the advanced functionalization and modification methods for the polysaccharide based-material; and d) their applications and uses in medical and pharmaceutical fields. Each chapter is written by world-renowned academics and practitioners on their field.This is an essential reference for students in biomedical, chemical, material, and microbiology engineering as well as researchers and professionals in the medical field.

Title is also available as part of a set: Polysaccharides of Microbial Origin (978-3-030-42216-5)

Introduction.- Glucans.- Levan.- Gums.- Bacterial alginate.- Kefiran Xylinan (Acetan).- Succinolycan and Glucuronan.- Colanic acid.- Colominic acid.- Cyanobacterial polysaccharides.- Glycosaminoglycans.- Chitin.- Chitosan.- Pullulan.- Scleroglucan and Schizophyllan.- Sulphated seaweed polysaccharides.- Polysaccharides produced by marine microalgae.- Marine biotechnology and microbiology.- Microalgae metabolites.- Biosynthesis of levan.- Biosynthesis of fungal polysaccharides.- Production of natural gums Isolation and purification of chitosan.- Production of scleroglucan.- Production of EPS from lactic acid bacteria.- Isolation of microbial polysaccharides.- Biosynthesis of microbial polysaccharides.- Properties of fungal polysaccharides.- Bioactivities of bacterial polysaccharides.- Surface properties of polysaccharides.- Antioxidant and antibacterial activities of polysaccharides.- Microalgal antioxidants for human health.- Gel properties of microbial polysaccharides.- Polysaccharides in bacterial biofilm.- Polysaccharide functionalizations for hydrogels.- Polysaccharide modifications for drug delivery systems.- Genetically modified microorganisms.- Sulphation of microbial polysaccharides.- Dextran pharmaceutical applications.- New applications of glycosaminoglycan.- Polysaccharides in cancer therapy.