Microbiome and Cancer

This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the establishment of cancers and that they can also contribute to the initiation, as well as persistence of, the cancers. Microbiome and Cancer covers the current knowledge of microbiome and its association with human cancers. It provides important reading for novices, senior undergraduates in cancer and microbiology, graduate students, junior investigators, residents, fellows and established investigators in the fields of cancer and microbiology. We cover areas related to known, broad concepts in microbiology and how they can relate to the ongoing discoveries of the micro-environment and the changes in the metabolic and physiologic states in that micro-environment, which are important for the ongoing nurturing and survival of the poly-microbial content that dictates activities in that micro-environment.

We cover the interactions of microorganisms associated with gastric carcinomas, which are important for driving this particular cancer. Additional areas include oral cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin’s and non-Hodgkin’s lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers. This book covers the metabolic changes that occur because of infection and their support for development of cancers, chronic infection and development of therapeutic strategies for detection and control of the infection.

The field of microbiome research has exploded over the last five years, and we are now understanding more and more about the context in which microorganisms can contribute to the onset of cancers in humans. The field of microbiome research has demonstrated that the human body has specific biomes for tissues and that changes in these biomes at the specific organ sites can result in disease. These changes can result in dramatic differences in metabolic shifts that, together with genetic mutations, will produce the perfect niche for establishment of the particular infection programmes in that organ site. We are just beginning to understand what those changes are and how they influence the disease state. Overall, we hope to bring together the varying degrees of fluctuations in the microbiome at the major organ sites and how these changes affect the normal cellular processes because of dysregulation, leading to proliferation of the associated tissues.

Chapter 1: Microbiome and Human Malignancies.- Chapter 2: Infection based Gastric cancers.- Chapter 3: Role of Infectious agents on development of Esophageal carcinomas.- Chapter 4: Viruses and glioblastoma: affliction or opportunity.- Chapter 5: The microbiome and its contribution to skin cancer.- Chapter 6: The role of the human virome in hematologic malignancies.- Chapter 7: Association of microbes with breast cancer.- Chapter 8: The Microbiome associated with Lung Cancer.- Chapter 9: Mesothelioma and Simian Virus 40 Infection.- Chapter 10: Infections related to development of Head and Neck Cancers.- Chapter 11: Microbiota, infectious organisms and Ovarian Cancer.- Chapter 12: Hepatocellular Cancer induced by Infection.- Chapter 13: Manipulation of the Host Immune Response by Small DNA tumor Viruses.- Chapter 14: Innate immune pattern recognition and the development of intestinal cancer.- Chapter 15: Microbial Metabolites in Cancer Promotion or Prevention.- Chapter 16: Rapid Synthetic DNA vaccine development for emerging infectious disease outbreaks.- Chapter 17: Future Perspectives: Microbiome, cancer and therapeutic promise.- Index