Atlas of Osteoarthritis

Nigel Arden, MBBS, FRCP, MSc, MD, is Professor of Rheumatology, Director of the Musculoskeletal Epidemiology Unit and the Oxford Musculoskeletal BioBank, he is also Deputy Director of the Oxford Biomedical Research Unit at Oxford University. Professor Arden trained at St Thomas's Hospital, London, where he also completed four years of research into the genetics of osteoporosis. During this time, he gained an MSc in Epidemiology and an MD. In 1998 he spent six months as Visiting Professor in Epidemiology at the University of San Francisco. In February 2000 he commenced his post as Consultant Rheumatologist at Southampton General Hospital, and Senior Lecturer in Rheumatology at the University of Southampton. He became a Professor of Rheumatic Diseases in Southampton in 2008 and at the University of Oxford in 2011. He is a Member of the National Osteoporosis Society Scientific Advisory Board; he is an International Osteoporosis Foundation Scientific Ambassador and sits on the European League Against Rheumatism (EULAR) Osteoarthritis Guideline Committee and the Osteoarthritis Research Society International (OARSI) Guidelines Committee. He has published over 200 research papers and 5 books. Francisco J. Blanco, MD, PhD, is Director of Research in the Biomedical Research Center of A Coruña (INIBIC) and Associate Professor of Medicine at the Universidad de Santiago de Compostela, Galicia, Spain. He was a Research Fellow at the University of California San Diego, USA. Currently, Dr Blanco works as a rheumatologist in clinic at the Hospital Universitario A Coruña. His research group is focused on the cellular and molecular mechanisms of osteoarthritis, and on the search of biomarkers useful for diagnosis, prognosis and therapeutic response of rheumatic diseases. He is President of the Research and Training Committee of OARSI. He is a member of the CIBER-BBN (Bioengineer, Biomaterials and Nanomedicine) and the Proteo-Red (Spanish Network of Proteomics). Dr Blanco isDirector of the Catedra-Bioiberica at A Coruña University and a member of the Editorial Board of the Osteoarthritis and Cartilage, Arthritis Research and Therapy, Open Arthritis Journal, Open Proteomics Journal and Reumatologia Clínica. Cyrus Cooper MA, DM, FRCP, FFPH, FMedSci, is Professor of Rheumatology and Director of the Medical Research Council (MRC) Lifecourse Epidemiology Unit; Vice-Dean of the Faculty of Medicine at the University of Southampton; and Professor of Musculoskeletal Science at the University of Oxford. Professor Cooper leads an internationally competitive programme of research into the epidemiology of musculoskeletal disorders, most notably osteoporosis. His key research contributions have been: discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood; demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone mineral accrual in childhood; characterization of the definition and incidence rates of vertebral fractures; and leadership of large pragmatic randomised controlled trials of calcium and vitamin D supplementation in the elderly as immediate preventative strategies against hip fracture. He is Chairman of the Committee of Scientific Advisors, International Osteoporosis Foundation; Chair of the MRC Population Health Sciences Research Network; Associate Director of Research at the University of Southampton Medical School; and Associate Editor of Osteoporosis International. He has published extensively (over 550 research papers) on osteoporosis and rheumatic disorders and pioneered clinical studies on the developmental origins of peak bone mass. Ali Guermazi, MD, PhD, is a radiologist with expertise in imaging of musculoskeletal diseases. Currently, he is Professor of Radiology, Section Chief of Musculoskeletal Imaging and Director of the Quantitative Imaging Center at Boston University School of Medicine. He leads a research group focusing on theapplication of

This Atlas provides an up-to-date and comprehensive overview of the historical and current perspectives on osteoarthritis, including the pathophysiology and epidemiology of the disease. Written by leading authors in the field of osteoarthritis, the book discusses classification, etiology and risk factors for osteoarthritis, the disease course and determinants of osteoarthritis progression, clinical features and diagnosis as well as imaging methods to assess joint damage. The Atlas of Osteoarthritis concludes with the latest treatment updates including both nonpharmacological and pharmacological treatments, as well as surgical recommendations for patients with the disease.Osteoarthritis is the most common form of joint disease causing joint pain, stiffness, and physical disability among adults. It is an important issue for both the individual and society with its impact on public health continuing to grow as a result of the aging population, the rising prevalence of obesity, and the lack of definitive treatments to prevent or halt the progress of the disease.

Comprehensive review of classification, diagnosis, and treatment recommendations for osteoarthritis based on national and international guidelines

Introduction: historical and current perspectives on osteoarthritis.- Epidemiology of osteoarthritis.- Pathophysiology of osteoarthritis.- Clinical features and diagnosis of osteoarthritis.- Assessing joint damage in osteoarthritis.- Treatment of osteoarthritis.