Advanced Vaccine Research Methods for the Decade of Vaccines

Since the publication of our first book 'Vaccine Design: Innovative Approaches and Novel Strategies' in 2011, the field of vaccinology has advanced significantly. This has prompted the need for this new volume, which aims to distil the most important new findings to provide a timely overview of the field. As before the book has been divided into two main parts. The first explores in considerable depth the key innovations that we think are dramatically changing the field; both for preclinical as well as clinical vaccine research fields. Some of the topics covered include: applications of deep sequencing, cellular screens to interrogate the human T and B cell repertoires, microbial comparative genomics, quantitative proteomics, structural biology, novel strategies for vaccine administration, T-cell inducing vaccines, etc. The second part focuses on diseases for which current medical treatment is not sufficiently effective and that could be either prevented or treated by vaccination. The examples that we have used comprise very different diseases including infectious diseases (e.g. Malaria, Tuberculosis, HIV, and Staphylococcus aureus) as well as cancer. We believe that these will be the vaccines of the future, the 'vaccines for 2020'. This book is essential reading for everyone working in vaccine R&D in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all Microbiology libraries.

Since the publication of our first book 'Vaccine Design: Innovative Approaches and Novel Strategies' in 2011, the field of vaccinology has advanced significantly. This has prompted the need for this new volume, which aims to distil the most important new findings to provide a timely overview of the field. As before the book has been divided into two main parts. The first explores in considerable depth the key innovations that we think are dramatically changing the field; both for preclinical as well as clinical vaccine research fields. Some of the topics covered include: applications of deep sequencing, cellular screens to interrogate the human T and B cell repertoires, microbial comparative genomics, quantitative proteomics, structural biology, novel strategies for vaccine administration, T-cell inducing vaccines, etc. The second part focuses on diseases for which current medical treatment is not sufficiently effective and that could be either prevented or treated by vaccination. The examples that we have used comprise very different diseases including infectious diseases (e.g. Malaria, Tuberculosis, HIV, and Staphylococcus aureus) as well as cancer. We believe that these will be the vaccines of the future, the 'vaccines for 2020'. This book is essential reading for everyone working in vaccine R&D in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all Microbiology libraries.