Renaissance of Sickle Cell Disease Research in the Genome Era

This textbook is an important addition to the field because it will bring the research and clinical community up-to-date on the past, present and future direction for sickle cell disease (SCD) in the context of the Human Genome Project (HGP). There are a limited number of textbooks on SCD that covers the role of the four disciplines required to produce a successful cure of SCD. The volume begins with a history of the early efforts in SCD, the role of the federal government and a review of the HGP. Next, the major progress in clinical care including newborn screening, pain management, stroke, transfusion therapy and the standard of care are discussed. In part 3, readers will be updated on the impact of the HGP in basic research progress in the hemoglobinopathy disorders with a detailed description of gene therapy efforts, including past failures and recent succsses. Finally in part 4, the impact of genetic profiling is explored from the perspective of the African-American community, and the book closes with a global perspective on SCD in Europe and Africa.

Sickle Cell Disease: Demystifying the Beginnings (C Reid & G Rodgers); Sponsorship of Sickle Cell Disease Research by the National Institutes of Health: A Brief History and Projections for the Future (G L Evans & D G Badman); The Human Genome Project (B S Pace); Sickle Cell Disease: A Phenotypic Patchwork (K Smith-Whitley & B S Pace); Preventive Care and Advances in the Treatment of Sickle Cell Disease (C T Quinn & G R Buchanan); Sickle Cell Disease in Adults (J Haynes, Jr. & A Pack-Mabien); Pain in Sickle Cell Disease: A Multidimensional Construct (L J Benjamin & R Payne); Transfusion Therapy in Sickle Cell Disease (C Hoppe et al.); Hemoglobin S Polymerization, Just the Beginning (F A Ferrone); Damage to the Red Blood Cell Membrane in Sickle Cell Disease (S R Goodman & C Joiner); Fetal Hemoglobin for What Ails Sickle Hemoglobin (S F Ofori-Acquah & B S Pace); Genetic Modulation of Sickle Cell Disease (M H Steinberg & L T Swee); Molecular Framework of Hemoglobin Switching (S Fiering); Dynamic Nucleoprotein Structure of the s-Globin Locus: Establishing a Rational Molecular Basis for the Therapeutic Modulation of Hemoglobin Switching (E Bresnick et al.); Vertebrate Models for Sickle Cell Disease Research (B H Paw et al.); Stem Cell Biology (W Li & A W Flake); Bone Marrow Transplantation (R I Raphael & M C Walters); Genetically Engineered Cures: Gene Therapy for Sickle Cell Disease (P Malik & P Leboulch); Sickle Cell Disease: The Past, Present and Future Social and Ethical Dilemmas (V L Bonham, Jr. et al.); It Takes a Village to Cure Sickle Cell Disease (R Peterson & D Davis-Maye); Beyond National Borders: A Global Perspective on Advances in Sickle Cell Disease Research and Management, and New Challenges in the Genome Era (S F Ofori-Acquah & K Ohene-Frempong).