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Statistical Modeling in Clinical Trials
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Artikel-Nr:
9781848212145
Veröffentl:
2016
Seiten:
256
Autor:
Vladimir V. Anisimov
Gewicht:
226 g
Format:
250x150x0 mm
Sprache:
Englisch
Beschreibung:
Clinical trials at the confirmatory stage of drug development typically require a large number of patients recruited by many clinical centers. The design of multi-center clinical trials consists of several interconnected stages including patient recruitment planning, choosing a randomization scheme and a statistical method for analyzing patient responses on different treatments, and planning the drug supply to satisfy patient demand in different centers and regional depots.
This book concentrates on the discussion of the novel analytic statistical techniques for modeling and predicting patient recruitment, randomization and drug supply processes in multi-center clinical trials, provides practical recommendations and many examples using real-life case studies and simulation in R
This book concentrates on the discussion of the novel analytic statistical techniques for modeling and predicting patient recruitment, randomization and drug supply processes in multi-center clinical trials, provides practical recommendations and many examples using real-life case studies and simulation in R
Introduction
Chapter 1. Basic statistical concepts in clinical trials
Chapter 2. Models for patient recruitment in multicentre clinical trials
Chapter 3. Predictive patient recruitment modelling
Chapter 4. Event prediction in clinical trials with waiting time to response
Chapter 5. Statistical models in multicentre clinical trials
Chapter 6. Modelling randomization effects
Chapter 7. Drug supply predictive modelling
Chapter 8. Risk-based supply modelling tool
Chapter 9. Modelling & simulation examples
Index
Chapter 1. Basic statistical concepts in clinical trials
Chapter 2. Models for patient recruitment in multicentre clinical trials
Chapter 3. Predictive patient recruitment modelling
Chapter 4. Event prediction in clinical trials with waiting time to response
Chapter 5. Statistical models in multicentre clinical trials
Chapter 6. Modelling randomization effects
Chapter 7. Drug supply predictive modelling
Chapter 8. Risk-based supply modelling tool
Chapter 9. Modelling & simulation examples
Index