Synthetic Methods in Drug Discovery
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Synthetic Methods in Drug Discovery

Volume 1
 Web PDF
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ISBN-13:
9781782622086
Einband:
Web PDF
Seiten:
455
Autor:
David C Blakemore
Serie:
ISSN
eBook Typ:
PDF
eBook Format:
Web PDF
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:

This book highlights key synthetic methodologies that have real impact in drug discovery and facilitate delivery of drug molecules.

Synthetic Methods in Drug Discovery Volume 1 focusses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Suzuki-Miyaura Coupling; Negishi Coupling; Hiyama Coupling; Sonogashira Coupling; Heck Coupling; Palladium- and Copper-Catalysed C–N Cross-Coupling in Drug Discovery; Chan-Lam Coupling Reaction; C−H Activation Approaches to Molecules; Palladium-Catalyzed Decarboxylative Couplings; New Frontiers with Transition Metals